Heavy metals (HMs) are compounds that can be hazardous and impair growth of living organisms. Bacteria have evolved the capability not only to cope with heavy metals but also to detoxify polluted environments. Three heavy metal-resistant strains of and one of were isolated from the gold/copper Zijin mining site, Longyan, Fujian, China.
View Article and Find Full Text PDFIn this study, HepG2 cells were exposed to 6-hydroxy- 2,2',4,4'-tetrabromodiphenyl ether (6-OH-BDE-47) for 3 and 6 days for monitoring cytotoxic effects and alterations in its transcriptomic profile. MTT assay showed that cells exposed to 6-OH-BDE-47 (50 nM) exhibited 48.5% and 53.
View Article and Find Full Text PDFWe have evaluated the in vitro low dose hepatotoxic effects of two flame-retardants (BDE-47 and BDE-32) in HepG2 cells. Both congeners declined the viability of cells in MTT and NRU cell viability assays. Higher level of intracellular reactive oxygen species (ROS) and dysfunction of mitochondrial membrane potential (ΔΨm) were observed in the treated cells.
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