Publications by authors named "Hend A Mohammed"
Introduction: Anaphylaxis is a globally increasing allergic reaction that is often fatal. Recently, our previous study reported the possibility of using the modified natural products "sodium R-lipoate (NaRLA) and enzymatically modified isoquercitrin (EMIQ)" as potential novel safe agents against the non-immunological-degranulation of mast cells.
Methods: Here, we extended our previous findings by determining the antianaphylactic activity of 50 and 100 mg/kg body weight of NaRLA and EMIQ (given orally and prior to local or systemic challenge) in mice models of ovalbumin (OVA)-induced IgE-dependent active cutaneous anaphylaxis (ACA) and active systemic anaphylaxis (ASA) in comparison with sulfasalazine (SSZ, amast cell stabilizer).
Article Synopsis
- Anaphylaxis is a severe allergic reaction becoming more common, and current synthetic treatments often lead to harmful side effects, such as gastric ulcers.
- Researchers tested the safety and effectiveness of two natural compounds, sodium R-lipoate (NaRLA) and enzymatically-modified isoquercitrin (EMIQ), against traditional drugs in mice models showing allergic reactions and stress-induced ulcers.
- The results suggested that both NaRLA and EMIQ effectively reduced allergic responses and gastric damage without causing ulcers, indicating their potential as safer treatment options for anaphylaxis.