Introduction: Avascular necrosis of the bone is a very common finding in sickle cell disease (SCD). The malignant transformation of a pre-existing bone infarct is extremely rare, only few cases has been reported related to different etiologies one of which is SCD.
Presentation Of Case: 40 years old male, known to have SCD, he presented as a case of avascular necrosis of the left proximal femur.