Outcomes of UK military personnel treated with ice cold water immersion for exertional heat stroke.

Introduction: Despite mitigation efforts, exertional heat stroke (EHS) is known to occur in military personnel during training and operations. It has significant potential to cause preventable morbidity and mortality. International consensus from sports medicine organisations supports treating EHS with early rapid cooling by immersing the casualty in cold water.

Use of Lhasa Limited Products for the In Silico Prediction of Drug Toxicity.

Lhasa Limited have had a role in the in silico prediction of drug and other chemical toxicity for over 30 years. This role has always been multifaceted, both as a provider of predictive software such as Derek Nexus, and as an honest broker for the sharing of proprietary chemical and toxicity data. A changing regulatory environment and the drive for the Replacement, Reduction and Refinement (the 3Rs) of animal testing have led both to increased acceptance of in silico predictions and a desire for the sharing of data to reduce duplicate testing.

Impact of smallmouth bass predation on subyearling fall Chinook salmon over a broad river continuum.

Smallmouth bass () predation on subyearling fall Chinook salmon () was examined in the Snake River (USA) to identify seasonal and habitat-related changes in bass diets, and associated subyearling consumption and loss in various riverine and impounded reaches. Smallmouth bass diets reflected opportunistic foraging that at times showed predation on subyearlings is influenced by the consumption of other prey such as crayfish, sand roller (), and smaller invertebrates. Estimated loss of subyearlings was influenced by bass abundance and consumption rates.

Carbamates and ICH M7 classification: Making use of expert knowledge.

Carbamates are widely used in the chemical industry so understanding their toxicity is important to safety assessment. Carbamates have been associated with certain toxicities resulting in publication of structural alerts, including alerts for mutagenicity. Structural alerts for bacterial mutagenicity can be used in combination with statistical systems to enable ICH M7 classification, which allows assessment of the genotoxic risk posed by pharmaceutical impurities.

A quantitative in silico model for predicting skin sensitization using a nearest neighbours approach within expert-derived structure-activity alert spaces.

Dermal contact with chemicals may lead to an inflammatory reaction known as allergic contact dermatitis. Consequently, it is important to assess new and existing chemicals for their skin sensitizing potential and to mitigate exposure accordingly. There is an urgent need to develop quantitative non-animal methods to better predict the potency of potential sensitizers, driven largely by European Union (EU) Regulation 1223/2009, which forbids the use of animal tests for cosmetic ingredients sold in the EU.

A survey of metal and pesticide levels in stormwater retention pond sediments in coastal South Carolina.

During the summer of 2007, sediment samples were collected from 16 stormwater detention ponds and 2 reference ponds located in coastal South Carolina. The sediments were analyzed for more than 30 pesticides with current and historical uses, six polybrominated diphenyl ethers (PBDEs), and seven metals. The results are compared with established screening assessment parameters, with copper found to be the contaminant of highest concern.

Measurement of the total active 8B solar neutrino flux at the Sudbury Neutrino Observatory with enhanced neutral current sensitivity.

The Sudbury Neutrino Observatory has precisely determined the total active (nu(x)) 8B solar neutrino flux without assumptions about the energy dependence of the nu(e) survival probability. The measurements were made with dissolved NaCl in heavy water to enhance the sensitivity and signature for neutral-current interactions. The flux is found to be 5.

Constraints on nucleon decay via invisible modes from the Sudbury Neutrino Observatory.

Data from the Sudbury Neutrino Observatory have been used to constrain the lifetime for nucleon decay to "invisible" modes, such as n-->3nu. The analysis was based on a search for gamma rays from the deexcitation of the residual nucleus that would result from the disappearance of either a proton or neutron from 16O. A limit of tau(inv)>2 x 10(29) yr is obtained at 90% confidence for either neutron- or proton-decay modes.

Evidence-based practice: beliefs, attitudes, knowledge, and behaviors of physical therapists.

Background And Purpose: Little research has been done regarding the attitudes and behaviors of physical therapists relative to the use of evidence in practice. The purposes of this study were to describe the beliefs, attitudes, knowledge, and behaviors of physical therapist members of the American Physical Therapy Association (APTA) as they relate to evidence-based practice (EBP) and to generate hypotheses about the relationship between these attributes and personal and practice characteristics of the respondents.

Methods: A survey of a random sample of physical therapist members of APTA resulted in a 48.

Size exclusion chromatographic analysis of polyphenol-serum albumin complexes.

Formation of water-soluble polyphenol-protein complexes was investigated by size-exclusion chromatography (SEC). The combination of (-)-epigallocatechin gallate (EGCG) and bovine serum albumin (BSA), which did not form a precipitate after the solutions were mixed, showed an SEC peak due to complex formation 2-24 h after mixing. Peak size of the complex varied with time, suggesting slow change of the conformation of the protein accompanied by complexation.

The influences of dietary intakes and supplementation with selenium and vitamin E on reproduction diseases and reproductive efficiency in cattle and sheep.

Retained placenta, endometritis, cystic ovaries and low conception rates are often considered as interconnected conditions in cattle. Wide ranges in amounts of selenium and vitamin E supplements have been advised in late-pregnancy diets and, frequently, they can be synergistically beneficial. Animals at grass or with other green foods should be of adequate vitamin E status, but dietary selenium deficiencies are both more frequent and severe.

The influence of bracket type on the force delivery of Ni-Ti archwires.

This study investigated the force delivery of an 0.014 inch nickel-titanium (Ni-Ti) archwire used in combination with a range of commercially available bracket systems, and using a model based on an 'ideal' mandibular archform. The model aimed to replicate the clinical interbracket span.

Enhanced reproductive performance of ewes given a sustained-release multi-trace element/vitamin ruminal bolus.

A sustained-release multi-trace element/vitamin bolus has been devised for administration to ewes in advance of mating. Each bolus contained 5.3g Cu, 50mg Se, 90mg Co, 100mg I, 3.

The influences of dietary selenium and vitamin E intakes on milk somatic cell counts and mastitis in cows.

Dietary supplements of selenium and vitamin E in greater amounts than are required for nutritional adequacy can have complementary functions in reducing somatic cell counts and both the severity and duration of clinical mastitis. Selenium inadequacy is geographically widespread and can frequently be a year-round problem. In contrast, an adequate intake of fresh grass and quality grass silage or other green, leafy material should provide adequate vitamin E.

Sustained-release boluses to supply trace elements and vitamins to calves.

Cylindrical rumen boluses of a size (55 mm length x 18 mm diameter, density 2.9 g cm(-3)) appropriate for ruminating calves over 75 kg liveweight were constructed. The mean daily nutrient releases from two rumen boluses measured in rumen-cannulated cows were 62 mg Cu, 0.

The use of positron emission tomography in the evaluation of orofacial malignancy and disease.

Positron emission tomography (PET) is a relatively new imaging technique that depends on the uptake of radionuclides. It has improved imaging ability compared with other modalities. Three case presentations are described illustrating the application of 'PET' in the management of oral cancer.

Characterization of the tumor-promoting activity of m-chloroperoxybenzoic acid in SENCAR mouse skin and its inhibition by gallotannin, oligomeric proanthocyanidin, and their monomeric units.

m-Chloroperoxybenzoic acid (CPBA),which induces ornithine decarboxylase activity as much as 12-O-tetradecanoylphorbol-13-acetate (TPA), was tested for its ability to induce DNA synthesis, hydroperoxide (HPx) production, and tumor promotion in mouse epidermis in vivo. After an early inhibition, CPBA stimulates DNA synthesis, a response which is maintained between 16 and 72 h and maximal after two treatments. CPBA at 0.

Ability of m-chloroperoxybenzoic acid to induce the ornithine decarboxylase marker of skin tumor promotion and inhibition of this response by gallotannins, oligomeric proanthocyanidins, and their monomeric units in mouse epidermis in vivo.

m-Chloroperoxybenzoic acid (CPBA) was tested for its ability to induce the ornithine decarboxylase (ODC) marker of skin tumor promotion. In contrast to benzoyl peroxide, dicumyl peroxide, and 2-butanol peroxide, 5 mg of CPBA applied twice at a 72-h interval induce ODC activity at least as much as 3 micrograms of 12-O-tetradecanoylphorbol-13-acetate (TPA). ODC induction peaks 36 h after a single CPBA treatment but is maximal 5 h after two applications of CPBA at a 48-h interval.

The effectiveness of copper oxide powder as a component of a sustained-release multi-trace element and vitamin rumen bolus system for cattle.

Copper oxide powder administered in the form of two experimentally produced sustained-release rumen boluses significantly increased blood and liver copper concentrations in growing sheep. It was estimated that 7% of the copper released was stored in the liver. In two farm observation trials administration of two standard production boluses significantly increased blood copper concentrations in out-wintered suckler cows during late pregnancy and early lactation, and in growing cattle at grass in the summer over periods of at least 170 and 123 days, respectively.