Publications by authors named "Hemilce Karina Rosa Flete"
J Physiol Sci
September 2024
Article Synopsis
- The study explored how aging affects the histone variant H3.3 in the tibialis anterior muscle of mice, finding that H3.3 levels significantly increase with age and correlate with the repressive marker H3K27me3.
- Acute exercise enhanced gene expression in younger (8-week-old) mice but did not have the same effect in older (53-week-old) mice, who showed increased H3.3 and H3K27me3 levels at rest rather than in response to exercise.
- Although H3.3 accumulation in older mice is linked to repressive chromatin formation, it also seems to improve motor function when H3.3 is artificially expressed in younger mice, indicating
