Correction: Glycal mediated synthesis of piperidine alkaloids: fagomine, 4--fagomine, 2-deoxynojirimycin, and an advanced intermediate, iminoglycal.

[This corrects the article DOI: 10.1039/D2RA05224E.].

Glycal mediated synthesis of piperidine alkaloids: fagomine, 4--fagomine, 2-deoxynojirimycin, and an advanced intermediate, iminoglycal.

Glucal and galactal are transformed into 2-deoxyglycolactams, which are important building blocks in the synthesis of biologically active piperidine alkaloids, fagomine and 4--fagomine. In one of the strategies, reduction of 2-deoxyglycolactam--Boc carbonyl by lithium triethylborohydride (Super-Hydride®) has been exploited to generate lactamol whereas reduction followed by dehydration was utilized as the other strategy to functionalize the C-C bond in the iminosugar substrate. The strategies provide the formal synthesis of 2-deoxynojirimycin, nojirimycin and nojirimycin B.

Clerodane type diterpene as a novel antifungal agent from Polyalthia longifolia var. pendula.

Bioactivity-guided chemical examination of methanolic extract of leaves of Polyalthia longifolia var. pendula led to the isolation of the active constituent, a diterpene 1 which was identified as 16α-hydroxycleroda-3,13(14)Z-dien-15,16-olide on the basis of its spectral data. Among the tested strains, diterpene 1 was found to exhibit antifungal activities having MIC90 values of 50.