Application of Reflectance Transformation Imaging (RTI) to surface bone changes in paleopathology.

The analysis of surface bone changes is an essential aspect of the paleopathological examination of skeletal remains from archaeological and forensic contexts, and proper digital imaging is an indispensable aspect of the documentation of bone modifications. This paper evaluates the applicability of Reflectance Transformation Imaging (RTI) to the study of pathological bone surface changes in human remains. Forty-five samples of human bones and teeth from medieval and early modern Estonian cemeteries were photographed and subjected to RTI imaging to document the pathological conditions that typically result in subtle surface modifications.

Intermittent versus continuous cyproterone acetate in bone metastatic prostate cancer: results of a randomized trial.

Background: To compare intermittent treatment (IT) versus continuous treatment (CT) using cyproterone acetate (CPA) in bone metastatic prostate cancer patients, we conducted an open-label, multicenter randomized trial. Continuous androgen deprivation therapy is the standard treatment in metastatic prostate cancer. Intermittent treatment might maintain efficacy while toxicity and costs are reduced.