Ligand anchored poly(propyleneimine) dendrimers for brain targeting: Comparative in vitro and in vivo assessment.

The present investigation was aimed at developing various ligands-anchored dendrimers and comparing their brain targeting potential at one platform. Sialic acid (S), glucosamine (G) and concanavalin A (C) anchored poly(propyleneimine) (PPI) dendritic nanoconjugates were developed and evaluated for delivery of anti-cancer drug, paclitaxel (PTX) to the brain. MTT assay on U373MG human astrocytoma cells indicated IC50 values of 0.

Design, modeling, and performance evaluation of a novel dye cell for a high repetition rate dye laser.

In this paper, a new dye cell for transverse pumping was designed, modeled, and its performance in a narrow spectral width dispersive resonator, pumped by a high repetition rate copper vapor laser, was investigated. The scheme essentially involves the profiling of the cubical glass and stainless steel cylindrical surface such that convex-plano contour be present near the optical pumping region. The design is an amalgamation of straight and curved periphery to enhance the dye solution flow stabilities near the dye laser axis.