Formulation and evaluation of sustained release bioadhesive tablets of ofloxacin using 3(2) factorial design.

Background: Oral sustained release gastroretentive dosage forms offer many advantages for drugs having absorption from upper gastrointestinal tract and improve the bioavailability of medications that are characterized by narrow absorption window. The aim of current study was to design sustained release bioadhesive gastroretentive dosage form of ofloxacin.

Materials And Methods: A 3(2) full factorial design was employed to systematically study the drug release profile and bioadhesive strength.

Formulation development and in vitro evaluation of gastroretentive hollow microspheres of famotidine.

Background: The main aim of this study was to develop a gastroretentive, multiple-unit floating drug delivery system for a drug which is poorly absorbed from the lower gastrointestinal tract. Such a dosage form may provide an extended retention of drug in the upper gastrointestinal tract resulting in enhanced absorption and improved bioavailability.

Materials And Methods: Microspheres were prepared by the emulsion solvent diffusion method.