Exploring the Relationship Between CD 166 Expression and Breast Imaging Reporting and Data System (BI-RADS) Scores in Breast Cancer Patients and Healthy Volunteers.

Background: This research embarked on a crucial endeavor to clarify the connection between levels of CD166 expression and the established Breast Imaging Reporting and Data System (BI-RADS) grading system. Through a comprehensive exploration of this correlation, the objective was to ascertain if CD166 could function as an additional biomarker, enhancing the predictive effectiveness of the BI-RADS classification.

Method: This prospective observational study involved 81 women with histopathologically confirmed early breast tumors and 81 radiologically confirmed healthy breast volunteers.

Single-Isocenter Multiple-Target SRS Planning of Five to Ten Brain Metastases Using 5 mm Multileaf Collimator: Relationship between Prescription Dose, Number and Volume of Targets.

Objective: To propose an expression relating the number and volume of targets with the prescription dose in determining normal brain volume receiving 12 Gy dose (V12) for five to ten brain metastases treated in linear accelerator-based stereotactic radiosurgery (SRS) planning. To determine the volume of tumor that can be treated within the brain tolerance dose, for different SRS prescription doses.

Methods: Single-isocenter multiple-target (SIMT) SRS plans were devised for spherical targets that are modeled to simulate 47 tumor scenarios with varying tumor sizes and locations within the brain.

A Comprehensive Evaluation of Single Isocenter Multiple Target SRS Plans and the Analytical Relationship between Plan Quality Indices with the Number and Volume of Targets.

Objective: To study the relationship of plan quality indices with the number and volume of target for 5 to 10 brain metastases treated with LINAC-based Single Isocenter Multiple Target (SIMT) Stereotactic radiosurgery (SRS) planning and to determine the maximum volume of spherical targets treated without exceeding the normal tissue tolerances.

Methods: Spherical targets of 5 to 10 numbers per plan, with individual target volumes ranging from 0.025 cc to 11.

Fixed-dose combination of three drugs, i.e. LABA/LAMA/ICS for COPD: Results of a real-world study from India.

Background: The use of triple therapy with inhaled corticosteroids, long-acting beta-agonist and long-acting antimuscarinics has been shown to be beneficial in COPD patients who continue to have symptoms and exacerbations, despite receiving dual bronchodilator combinations. This study assessed the real-world effectiveness and safety of once-daily, fixed-dose combination of Tiotropium/Formoterol/Ciclesonide (TFC) (18 mcg/12 mcg/400 mcg) via dry powder inhaler (DPI) or metered dose inhaler (MDI) in patients with COPD.

Patients And Methods: In this 24-week, open-label, prospective, non-comparative, multicentre, real-world study, COPD patients requiring triple therapy as judged by their physician, were enrolled.

Immunofluorescence in oral lesions.

Immunofluorescence is an immunohistochemical method used to demonstrate the presence of antigen and antibodies in the tissues or serum. It is an auxiliary diagnostic tool for the autoimmune bullous and inflammatory disorders. It detects the and circulating immune deposits that are involved in the pathogenesis of immunobullous diseases.

Oral malignant melanoma: A case report with review of literature.

Oral mucosal melanoma is a rare malignancy with the tendency to metastasize and locally invade tissues more readily than other malignant tumor of the oral cavity. It occurs approximately four times more frequently in the oral mucosa of the upper jaw usually on the palate or alveolar gingiva. The chameleonic presentation of malignant melanoma, its asymptomatic condition, rarity of the lesion, poor prognosis and the necessity of a highly specialized treatment are factors that should be seriously considered by the involved health care provider.

Comparison of the salivary and the serum nitric oxide levels in chronic and aggressive periodontitis: a biochemical study.

Background And Objectives: Nitric oxide (NO) is a ubiquitous intercellular messenger molecule with important cardiovascular, neurological, and immune functions. In addition, it has been postulated that the pharmacological inhibition of NO or its actions may be therapeutically valuable in the disease management. The levels of nitric oxide may provide clues about the severity and the state of the underlying disease process.

Detection of Amp C beta lactamases production in Escherichia coli & Klebsiella by an inhibitor based method.

Background & Objective: Detection of AmpC-mediated resistance in Gram-negative organisms poses a problem due to misleading results in phenotypic tests. There are no recommended guidelines for detection of this resistance mechanism and there is a need to address this issue as much as the detection of extended spectrum beta lactamases (ESBLs) since both may co-exist and mask each other. Though resistance to cefoxitin is used as a screening test, it does not reliably indicate Amp C production.

Superantigens - concepts, clinical disease and therapy.

The term superantigen was introduced in microbiology and immunology only a decade ago. The unique feature of superantigen is that it bypasses the antigen processing mechanism and specifically binds to TCR v segment and forms a trimolecular complex along with major histocompatibility complex class II. Since its discovery, several studies have been carried out to unravel the properties of superantigens.

Detection of metallo betalactamase producing Pseudomonas aeruginosa in hospitalized patients.

Background & Objective: Metallo beta-lactamase (MBL)-mediated resistance to carbapenems is an emerging threat in hospital isolates of Pseudomonas aeruginosa. Though there are several screening methods to detect this enzyme production, the National Committee for Clinical Laboratory Standards (NCCLS) does not have performance standards documented so far. There is not enough information from the Indian subcontinent regarding the prevalence and the screening methods for these enzymes.

Genetic variability of begomoviruses associated with cotton leaf curl disease originating from India.

Cotton leaf curl disease (CLCuD) causing viruses belong to the Begomovirus genus of the family Geminiviridae. Most begomoviruses are bipartite with two molecules of circular single stranded DNA (A and B) encapsidated in icosahedral geminate particles. However, the begomoviruses associated with CLCuD have DNA-beta instead of DNA-B.

Craniopharyngioma presenting as 'mania'-case report.

We are reporting a case of craniopharyngioma presenting with features of mania. To our knowledge, this is the first reported case of craniopharyngioma with presenting features of mania- The patient is a six years old child with history of maniac behaviour of six months duration. There is no significant family history.

Intrathoracic foregut cyst (foregut duplication) associated with esophageal atresia.

Intrathoracic foregut duplication cysts are rare congenital foregut malformations that usually produce respiratory symptoms in early infancy. Surgical resection of this anomaly is usually followed by permanent cure. Two cases of intrathoracic foregut duplication cyst associated with esophageal atresia are reported.

Phimosis in boys.

Phimosis, defined as scarring of the tip of the prepuce, was studied prospectively in a series of 23 boys aged 4 to 11 years. There was little to support the contention that the condition is caused by trauma, or by ammoniacal or bacterial inflammation of the prepuce, nor could any other aetiological factor be identified. Histological examination of the foreskin showed the appearances of Balanitis Xerotica Obliterans in 20 of 21 specimens submitted for study.

Neonatal appendicitis.

Another example of neonatal appendicitis is presented, and the clinical details of 33 cases previously documented in the literature are reviewed. This rare condition is characterized by an inordinate delay in diagnosis, a high incidence of perforation of the appendix and a high mortality.

Closure of colostomy in infants and children.

A retrospective survey of 100 consecutive colostomy closures in infants and children is presented: the operative technique consisted of bowel resection and anastomosis, usually as a single layer, with intraperitoneal closure. Faecal fistula occurred in 5 cases and there were other major complications in 8 instances. Wound infection occurred in 43 patients.