Publications by authors named "Hema Manvi Koneru"
Diabetes mellitus represents a significant global health challenge, characterized by impaired insulin production and action, leading to elevated blood glucose levels. This systematic review investigates the association between gut microbiota composition and diversity, along with the structural and functional characteristics of the gut microbiome, and their implications for the risk, prevention, and management of both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, a comprehensive search across multiple databases yielded 16 studies that met the inclusion criteria.
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- Lipoprotein(a) [Lp(a)] is recognized as a key independent risk factor for atherosclerotic cardiovascular disease (ASCVD), prompting research into various lipid-lowering drugs that might reduce its levels.
- A systematic review of 29 studies showed that traditional lipid-lowering agents like statins and fibrates generally do not significantly affect Lp(a) concentrations, whereas Lp(a) apheresis and PCSK-9 inhibitors were effective.
- Emerging RNA-targeting therapies, such as anti-sense oligonucleotides, demonstrated promise in lowering Lp(a) levels, but it's still unclear if these reductions will lead to fewer cardiovascular events in patients.
Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent condition. It occurs more commonly in older patient populations with multiple comorbidities, such as hypertension, diabetes, and obesity. However, managing HFpEF has been challenging due to its complex pathophysiology, and medications effective for heart failure with reduced ejection fraction (HFrEF) have not shown similar efficacy in HFpEF.
View Article and Find Full Text PDFDiabetes mellitus (DM) is a chronic metabolic disorder that affects millions of individuals worldwide. With an increasing prevalence, understanding its implications for respiratory health is essential. Chronic lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), significantly impact morbidity and healthcare costs, with COPD alone accounting for substantial economic burdens.
View Article and Find Full Text PDFCeliac disease, a serious autoimmune disease, is triggered by the ingestion of gluten. It is associated with many gastrointestinal and extraintestinal symptoms. The cornerstone of treatment is a strict gluten-free diet (GFD).
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