Publications by authors named "Hem C Sati"
Background: Ovulation induction (OI) in patients with polycystic ovary syndrome (PCOS) remains challenging, and several biomarkers have been evaluated for their ability to predict ovulation. The predictive ability of candidate biomarkers, particularly with letrozole-based therapy in infertile PCOS women, remains inconclusive as it is yet to be evaluated in a prospective study.
Aim: To assess the role of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinising hormone (LH)/FSH ratio, testosterone and free androgen index (FAI) as predictors of ovarian response to letrozole-based OI therapy during OI cycles in infertile women with PCOS from North India.
Article Synopsis
- Pelvi-Ureteric Junction Obstruction (PUJO) is a leading cause of hydronephrosis in children, and while ultrasonography is useful, it can't determine if an obstruction is present; thus, Ureteric jets through color Doppler ultrasound are being studied for this purpose.
- The study aimed to evaluate Ureteric Jet Frequency (UJF) and Relative Jet Frequency (RJF) in children with unilateral PUJO before and after administering furosemide, assessing their effectiveness for diagnosis and post-operative monitoring.
- Results showed that UJF was significantly lower on the obstructed side, but the difference was not significant when compared to controls; after surgery, both UJF and RJF increased, indicating their potential utility in
Objective: This study primarily aimed to assess the expression of MUC4 in patients with pancreatic ductal adenocarcinoma (PDAC) as compared with controls and assess its clinical relevance.
Materials And Methods: Serum MUC4 levels and MUC4 gene expression in snap-frozen tissue were analyzed through surface plasmon resonance and quantitative polymerase chain reaction, respectively. Tumor tissues and control tissues were analyzed for MUC4 and other mucins through immunohistochemistry.
Introduction: Nutrition plays an important role in management of acute pancreatitis (AP) and decreases its severity and infectious complications. Various formulations of enteral nutrition (EN) are available and are costly. For developing countries, cost and availability is a major issue and kitchen-based diet should be explored in patients with AP.
View Article and Find Full Text PDFBackground And Aims: Lumbar vertebral bone attenuation, measured in Hounsfield units (HU) can indirectly indicate the bone mineral density (BMD). The aim of this study is to determine the optimal HU threshold on abdominal computed tomography (CT) scans to detect osteopathy in patients with chronic pancreatitis (CP).
Methods: This cross-sectional study included patients with CP who underwent CT scans to measure HU at L1 to L4 vertebrae.
Background & Objectives: Vitamin D plays an important role in bone metabolism, and liver is the intermediary site of vitamin D metabolism. The purpose of this study was to study the prevalence of vitamin D deficiency and bone health in patients with cirrhosis.
Methods: Prospectively, serum 25-hydroxy vitamin D [25(OH)D] level were assessed in cirrhotics by chemiluminescence method.
Article Synopsis
- The study tested whether the Glasgow Coma Scale-Pupils (GCS-P) score is a better predictor of mortality than the traditional Glasgow Coma Scale (GCS) in patients with traumatic brain injury (TBI).
- Researchers conducted a prospective study with 573 adult TBI patients, analyzing their GCS and GCS-P scores upon ICU admission along with various clinical data to determine outcomes.
- Results showed that both GCS and GCS-P had similar predictive power for mortality and functional outcomes at discharge and 6 months later, indicating that while GCS-P is effective, it is not superior to GCS in predicting these outcomes.
Article Synopsis
- Limb amputation is a very old medical procedure that has been done for over 2500 years, mainly when trauma occurs, especially in young people in countries like India.
- Over 547 patients had limb amputations from 2015 to 2019, with most cases caused by road traffic injuries, and many had serious issues like hemorrhagic shock.
- The study found that factors like how quickly patients got help, their injury severity, and infections were important in deciding whether they recovered or not, with 8.6% of the patients sadly passing away during the study.
MicroRNAs associated with the Notch pathway play a critical role in the progression of pancreatic carcinoma. Our aim was to study the clinical significance of miR-107 and NOTCH2 in pancreatic ductal adenocarcinoma (PDAC). The circulating miR-107 levels in PDAC and controls were determined by qPCR.
View Article and Find Full Text PDFAim: To study polymorphisms in glutathione-S-transferases (GST-T1, GST-M1, GST-P1) and uridine-5'-diphosphate-glucuronosyl-transferases (UGT1A7) genes and the risk of developing chronic pancreatitis (CP) associated with these polymorphisms.
Methods: This study included 49 alcoholic and 51 idiopathic chronic pancreatitis patients, 50 alcohol addicts and 50 healthy controls. Polymorphism(s) in GST-T1 and GST-M1 genes were assessed by multiplex polymerase chain reaction (PCR), while PCR-radiofrequency lesioning (RFLP) was employed to assess the same in GST-P1 and UGT1A7 genes.
Background: Acute kidney injury (AKI) considerably increases the risk of short-term mortality in acute-on-chronic liver failure (ACLF) but predicting AKI is not possible with existing tools. Our study aimed at discovery of AKI biomarkers in ACLF.
Methods: This observational study had two phases- (A) Discovery phase in which quantitative proteomics was carried-out with day-of-admission plasma from ACLF patients who initially had no-AKI but either progressed to AKI (n=10) or did not (n=9) within 7 days of admission and, (B) Validation phase in which selected biomarkers from the discovery phase were validated by ELISA in a larger set of ACLF plasma samples (n=93) followed by sub-group analyses.
Background: Rapid conversion from prediabetes to diabetes and frequent postprandial hyperglycemia (PPHG) is seen in Asian Indians. These should be the target of dietary strategies.
Objectives: We hypothesized that dietary intervention of preloading major meals with almonds in participants with prediabetes will decrease overall glycemia and PPHG.
Purpose: The aim of the study was to estimate centiles by using improved statistical smoothing procedure, the Box-Cox power-exponential (BCPE) method, in urban northern Indian adolescents aged 11-17 years.
Materials And Methods: Data were collected cross-sectionally by measuring specific anthropometric features such as height, weight, and mid-upper arm circumference in school-based adolescents aged 11-17 years including both boys (n = 838) and girls (n = 788) enrolled in government educational institutions in urban Delhi. We used a state-of-the-art statistical methodology (BCPE method) to establish centile curves.
Background: Surge of SARS CoV-2 infections ascribed to omicron variant began in December 2021 in New Delhi. We determined the infection and reinfection density in a cohort of health care workers (HCWs) along with vaccine effectiveness (VE) against symptomatic infection within omicron transmission period (considered from December 01, 2021 to February 25, 2022.
Methods: This is an observational study from the All India Institute of Medical Sciences, New Delhi.
Objective: The majority of lung cancers are diagnosed at an advanced stage; the reasons for which are variable and unclear.
Methods: Lung cancer patients were evaluated prospectively to quantify various timelines and establish reasons for delays. Timelines were defined as time intervals between symptom onset, first physician visit, first specialist visit, date of diagnosis and treatment.
Background: Indian data on treatment outcomes and survival in advanced non-small cell lung cancer (NSCLC) remain scarce.
Materials And Methods: A retrospective review of 537 advanced NSCLC patients treated at a tertiary care facility in North India from January 2008 to March 2018 was done to assess treatment response and survival in terms of objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS).
Results: Median age of enrolled patients was 60 years (range: 26-89 years).
Acceptability of artificial intelligence among Indian dermatologists.
Indian J Dermatol Venereol Leprol
March 2022
Objective: High burden of anaemia exists amongst rural adolescent girls in India. The objective of this study was to characterise anaemia in school going adolescent girls in rural Haryana, India.
Design: Linear and multiple logistic regression analysis of data collected prior to an intervention trial was conducted.
Aims: The utility of beta-blocker therapy in infants with heart failure (HF) due to significant left-to-right shunt lesions is not known. The study aimed to assess the efficacy and safety of propranolol in infants with HF due to moderate-to-large ventricular septal defect (VSD).
Methods: The prospective randomized trial included 80 infants with HF and moderate-to-large VSD, randomly allocated to receive either conventional therapy alone ( = 40) or propranolol plus conventional therapy ( = 40).
To study heterogeneity in SARS-CoV-2 IgG response titre in patients recovered from COVID-19.
Monaldi Arch Chest Dis
September 2021
The COVID-19 pandemic caused a serious health challenge to the entire mankind. The association between clinical characteristics of disease and formation of neutralizing antibodies have not well studied. A prospective study was conducted for patients recovered from confirmed SARS-CoV-2 infections from 1st August 2020 to 28th February 2021, to study the association between SARS-CoV-2 IgG antibody response titres and clinical characteristics of the disease.
View Article and Find Full Text PDFIntroduction: In patients with cirrhosis, highly prevalent vitamin D deficiency and low bone mineral density (BMD) increase the burden of disease, and role of vitamin D supplementation is not clear. So, our aim was to determine the effect of vitamin D supplementation on vitamin D level and BMD in patients with cirrhosis.
Methods: Patients with cirrhosis (18-60 years) of any etiology were enrolled.
Introduction: Data regarding knowledge and attitude about COVID-19, the prevalence of acceptance of hydroxychloroquine prophylaxis and anxiety amidst COVID-19 pandemic among health care students/professionals in India is scarce.
Material And Methods: A cross-sectional study was conducted during May 2020, using an online survey via Google forms. A self-administered validated structured questionnaire was applied, which comprised 28 questions among health care students/professionals at a tertiary care centrein North India.
Aim: To verify if transverse acetabular ligament (TAL) can be used as an anatomical landmark to reliably orient the cup in primary total hip arthroplasty and compare it to acetabular cups placed with the help of mechanical angle guide (MAG) device.
Materials And Methods: Thirty Five patients with primary total hip arthroplasty, all performed by the same surgeon were included in the study. All patients had undergone surgery by anterolateral approach and all were cementless total hip arthroplasty.