Cytotoxic necrotizing factor 1 hinders colon tumorigenesis induced by colibactin-producing in mice.

Colorectal cancer (CRC) patients are frequently colonized by colibactin-producing (CoPEC) (>40%), which enhances tumorigenesis in mouse models of CRC. We observed that 50% of CoPEC also contains the gene, which encodes cytotoxic necrotizing factor-1 (CNF1), an enhancer of the eukaryotic cell cycle. The impact of its co-occurrence with colibactin (Clb) has not yet been investigated.