Publications by authors named "Heloise Adeli Grockoski"
Article Synopsis
- Chemotherapy-induced peripheral neuropathy (CIPN) affects a significant percentage of patients receiving paclitaxel, leading researchers to explore TZD-A1, a new potential treatment.
- The study involved various analyses to assess TZD-A1's interaction with PPARγ, its safety, and its effects on CIPN in mice, revealing a positive safety profile and effective reduction of neuropathy symptoms.
- Results suggest that TZD-A1 mitigates the negative effects of paclitaxel by preventing neuroinflammation and mitochondrial damage, making it a promising candidate for enhancing the quality of life in cancer patients.
Ethnopharmacological Relevance: Synadenium grantii Hook. f., popularly known as "janaúba" or "leiterinha", is used in the folk medicine to treat gastric disorders, some types of neoplasias and inflammatory diseases.
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