Ultrasound-assisted Extraction of Ursolic Acid from the Flowers of Linn (Rubiaceae) and Antiproliferative Activity of Ursolic Acid and Synthesized Derivatives.

Background: Linn (Rubiaceae) is an evergreen shrub with bright scarlet colored flowers found in several tropical and subtropical countries. It is used as an ornamental and medicinal plant. Phytochemical studies revealed that its major special metabolites are triterpene acids, such as ursolic and oleanolic acid.

Antileishmanial pyrazolopyridine derivatives: synthesis and structure-activity relationship analysis.

Three series of 4-anilino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic esters were synthesized as part of a program to study potential anti-Leishmania drugs. These compounds were obtained by a condensation reaction of 4-chloro-1H-pyrazolo[3,4-b]pyridine with several aniline derivatives. Some of them were also obtained by an alternative pathway involving a Mannich-type reaction.