Publications by authors named "Helna B Mary"
Article Synopsis
- Achieving ultra-long-term release of hydrophilic drugs (over six months) poses a challenge for existing long-acting injectables (LAIs), which often face issues like burst release and rapid drug diffusion due to their design.
- A new injectable platform called ISCD, created using a methacrylated ultra-low molecular weight pre-polymer (polycaprolactone), addresses these issues by minimizing burst release and controlling water exchange through a dense mesh network.
- Studies show that ISCD successfully delivers various hydrophilic drugs (including antiretrovirals and antibiotics) and enables co-delivery of multiple drugs, with the potential for improved adherence in chronic conditions while surpassing the one-month drug release standard of existing LA
Despite four decades of research in intra-articular drug delivery systems (DDS) and two decades of advances in disease-modifying osteoarthritis drugs (DMOADs), there is still no clinically available disease-modifying therapy for osteoarthritis (OA). Multiple barriers compromise intra-articular DMOAD delivery. Although multiple exciting approaches have been developed to overcome these barriers, there are still outstanding questions.
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