Synthesis and antitumor activity of some novel quinazoline derivatives bearing the biologically active thione moiety.

The reactivity of isothiocyanate 1 towards some nitrogen nucleophils was investigated. Thus, interaction of 1 with p-flouroaniline, benzylamine, 2-aminopyridine, and 4-aminoantipyrine yielded the corresponding quinazoline derivatives 3-7, respectively. Triazolo-quinazoline 10 was obtained in good yield via reaction of isothiocyanate 1 with thiosemicarbazide.