Andean medicinal plants and their secondary metabolites: Connections between Aymara traditional medicine and modern pharmacology.

This review examines Aymara traditional medicine, which is deeply rooted in cultural perceptions of health and disease, and its utilization of medicinal plants rich in secondary metabolites-such as flavonoids, alkaloids, and saponins-to support immune function, emphasizing the synergy between ancestral knowledge and modern scientific research. Adhering to PRISMA 2020 guidelines, this review incorporates empirical studies from 2013 to 2024 on secondary metabolites and Aymara medicine, with a focus on the immunomodulatory effects of plants, while excluding non-indexed or irrelevant studies. Potential limitations include publication bias and reliance on secondary data.