Antibacterial activity of paroxetine against and possible mechanisms of action.

To evaluate the antibacterial activity of paroxetine alone and associated with oxacillin against isolates of methicillin-sensitive and -resistant . The broth microdilution and checkerboard techniques were used, with investigation of possible mechanisms of action through flow cytometry, fluorescence microscopy and molecular docking, in addition to scanning electron microscopy for morphological analysis. Paroxetine showed a MIC of 64 μg/ml and bactericidal activity, mostly additive interactions in combination with oxacillin, evidence of action on genetic material and membrane, morphological changes in microbial cells and influence on virulence factors.

Activity of amlodipine against : association with oxacillin and mechanism of action.

This study was designed to evaluate the antimicrobial activity of amlodipine against strains. The antimicrobial activity of amlodipine was evaluated by the broth microdilution method and its interaction with oxacillin was evaluated by checkerboard assay. The possible mechanism of action was evaluated by flow cytometry and molecular docking techniques.

Activity of arginine-phenylalanine and arginine-tryptophan-based surfactants against .

This study aimed to evaluate the antibacterial effect of two new cationic surfactants based on phenylalanine-arginine (LPAM) and tryptophan-arginine (LTAM). Antibacterial activity, mechanism of action and interactions with enzymes were measured through microbiological, flow cytometry and molecular docking assays, respectively. These compounds showed antibacterial activity in the range of 4.

Antifungal activity of dexamethasone against fluconazole-resistant and its activity against biofilms.

The present study investigated the antifungal action of dexamethasone disodium phosphate (Dex). Susceptibility testing was performed using the Clinical & Laboratory Standards Institute protocol; M27-A3, checkerboard test and biofilm were evaluated with two isolates of , hyphal production test, molecular docking analysis and flow cytometry analysis. Dex and fluconazole (FLC) together had a synergistic effect.

Gallic acid leads to cell death of by the apoptosis mechanism.

To evaluate the antifungal activity of gallic acid (GA) against the strains of spp. resistant to fluconazole and to determine its mechanism of action. Antifungal activity was evaluated using the broth microdilution and flow cytometry techniques.

Synergistic activity of dobutamine combined with azoles and its mechanism of action against strains of .

To evaluate the antifungal effect of dobutamine against as well as its synergism with azoles and its action on biofilm. The M27-A3 protocol and flow cytometry were used for elucidation of the possible mechanism of action. The tested isolates presented MICs ranging from 2 to 32 μg/ml for dobutamine, with fungistatic effect.

Etomidate inhibits the growth of MRSA and exhibits synergism with oxacillin.

The purpose of this study was to evaluate the antimicrobial activity of the anesthetic etomidate against strains of MRSA and biofilms. The antibacterial effect of etomidate was assessed by the broth microdilution method. To investigate the probable action mechanism of the compound flow cytometry techniques were used.

Antifungal activity of β-lapachone against azole-resistant spp. and its aspects upon biofilm formation.

The purpose of this study was to assess the antifungal effect of β-lapachone (β-lap) on azole-resistant strains of spp. in both planktonic and biofilm form. The antifungal activity of β-lap was evaluated by broth microdilution, flow cytometry and the comet assay.

Synergistic anticandidal activity of etomidate and azoles against clinical fluconazole-resistant isolates.

The purpose of this study was to evaluate the effect of etomidate alone and in combination with azoles on resistant strains of spp. in both planktonic cells and biofilms. The antifungal activity of etomidate was assessed by the broth microdilution test; flow cytometric procedures to measure fungal viability, mitochondrial transmembrane potential, free radical generation and cell death; as well detection of DNA damage using the comet assay.