Publications by authors named "Heling Bao"

Importance: Understanding the association of artificial intelligence (AI) with physician burnout is crucial for fostering a collaborative interactive environment between physicians and AI.

Objective: To estimate the association between AI use in radiology and radiologist burnout.

Design, Setting, And Participants: This cross-sectional study conducted a questionnaire survey between May and October 2023, using the national quality control system of radiology in China.

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Background: Periconceptional folic acid supplementation (FAS) is widely recommended. However, the role of periconceptional FAS on neonatal birth weight remains unclear.

Objectives: This study aimed to explore the independent effects of periconceptional FAS on risks of small for gestational age (SGA) and large for gestational age (LGA) and to test the potential mediation role of maternal homocysteine (Hcy) during pregnancy on the above significant associations.

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Article Synopsis
  • * It included over 85,000 participants, revealing an anti-HEV IgG prevalence of 18.02% and an incidence rate of HEV seroconversion of 1.79 per 100 person-years during a median follow-up of 1.2 years.
  • * Key risk factors for HEV seroconversion identified include being 60 or older, low socioeconomic status, and residing in coastal areas or regions with high drainage density and anti-HEV IgG prevalence.
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To investigate the epidemiological characteristics of anemia of varying severity among women of reproductive age, we conducted a nationwide, cross-sectional study between January 1, 2019 and December 31, 2019, including 4 184 547 nonpregnant women aged 18-49 years from all 31 provinces in the mainland of China. Anemia was defined as having hemoglobin concentration < 120.0 g/L and categorized as mild, moderate, and severe.

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What Is Already Known About This Topic?: Anemia is a significant public health issue affecting women globally. Prior studies in China predominantly concentrated on anemia in pregnant or reproductive-age women, leaving a gap in available data concerning anemia in non-pregnant women of all age groups in China.

What Is Added By This Report?: In 2021, the prevalence of anemia and moderate to severe anemia among women aged 18 years and older in urban China was 14.

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Background: Breast cancer (BC) risk-stratification tools for Asian women that are highly accurate and can provide improved interpretation ability are lacking. We aimed to develop risk-stratification models to predict long- and short-term BC risk among Chinese women and to simultaneously rank potential non-experimental risk factors.

Methods: The Breast Cancer Cohort Study in Chinese Women, a large ongoing prospective dynamic cohort study, includes 122,058 women aged 25-70 years old from the eastern part of China.

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Differentiated thyroid cancer (DTC) is increasingly common in women of reproductive age. However, whether pregnancy increases the risk of DTC progression/recurrence after treatment remains controversial. The study aimed to assess the association of pregnancy with risk of progression in patients previously treated for DTC.

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Background: Prompt recognition of patients predisposed to acute kidney injury (AKI) within 72 hours of intensive care unit (ICU) admission holds significant clinical importance as it can considerably lower mortality rates. However, existing AKI prediction models often require complex data collection yet yield only moderate performance. This study aims to develop a straightforward and efficient AKI prediction model, providing ICU physicians with a powerful tool to expedite the detection of AKI patients.

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Background & Aims: This study aimed to estimate the prevalence of liver steatosis and fibrosis in the general population and populations with potential risk factors in China, so as to inform policies for the screening and management of fatty liver disease and liver fibrosis in general and high-risk populations.

Methods: This cross-sectional, population-based, nationwide study was based on the database of the largest health check-up chain in China. Adults from 30 provinces who underwent a check-up between 2017 and 2022 were included.

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Background: The 2021 World Health Organization (WHO) guidelines for cervical cancer screening recommend human papillomavirus (HPV) DNA or mRNA testing. Artificial intelligence (AI)-assisted liquid-based cytology (LBC) systems also have the potential to facilitate rapid scale-up of cervical cancer screening. We aimed to evaluate the cost-effectiveness of AI-assisted LBC testing, compared with the manual LBC and HPV-DNA testing, for primary cervical cancer screening in China.

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Background: Some clinicians used levothyroxine (LT4) treatment for mild subclinical hypothyroidism (SCH) pregnant women (2.5 < thyroid-stimulating hormone (TSH) ≤ the pregnancy-specific reference range with normal free thyroxine (FT4) level) with thyroid peroxidase antibody negative (TPOAb), although the recent clinical guideline did not recommend it. It is unknown whether LT4 treatment for pregnant women with mild SCH and TPOAb have impact on fetal growth.

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What Is Already Known About This Topic?: In 2015, only 18.9% of adult women underwent breast cancer screening in China.

What Is Added By This Report?: Breast cancer screening coverage for women aged 20 years and above in China reached 22.

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What Is Already Known About This Topic?: Breast cancer awareness plays a crucial role in promoting screening attendance, enabling early detection, and improving survival rates associated with breast cancer. Nevertheless, a persistent issue is the low public awareness of breast cancer warning signs and risk factors.

What Is Added By This Report?: Breast cancer awareness rate was 10.

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What Is Already Known About This Topic?: Psychological and lifestyle factors are known to potentially play a significant role in the development of breast cancer. However, current evidence-based studies present controversial findings on the associations between depression, sleep duration, and breast cancer risk.

What Is Added By This Report?: This study investigated the potential risk factors of depressive symptoms and short sleep duration for breast cancer within the Breast Cancer Cohort Study in Chinese Women.

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Background: Limited studies have examined the effect of prenatal exposure to particulate matter with diameter of <2.5 µm (PM2.5) and <1 μm (PM1) on fetal growth using ultrasound measurements with inconsistent results.

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What Is Already Known About This Topic?: The World Health Organization set a 2030 target of 70% cervical cancer screening coverage for women aged 35-45 years. Coverage stood at 37% in China in 2015.

What Is Added By This Report?: In 2018-2019, China's cervical cancer screening coverage reached 43.

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What Is Already Known About This Topic?: Human papillomavirus (HPV) type-specific strategies play a key role in the prevention of cervical intraepithelial neoplasia (CIN), but evidence on the HPV type-specific prevalence in CIN is limited.

What Is Added By This Report?: This multicentric study estimates the prevalence of high-risk HPV types in CIN cases and the associations of HPV infection patterns with high-grade CIN in China in 2017-2018.

What Are The Implications For Public Health Practice?: Population-based prevention strategies should give preference to HPV-16 and 18, and strategies for non-16/18 high-risk HPV are essential for the elimination of cervical cancer.

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Article Synopsis
  • Particulate matter (PM) exposure negatively impacts respiratory and circulatory health, and this study investigates how it affects hypertensive disorders of pregnancy (HDPs) during the crucial period from preconception to delivery.
  • Researchers analyzed data from 22,570 pregnant women, focusing on those diagnosed with gestational hypertension and preeclampsia, and utilized satellite data to measure PM exposure linked to participants' addresses.
  • Results indicated that exposure to PM significantly increases the risk of HDPs, particularly noting the critical influence from the 5th week before conception to the 6th week of pregnancy, with a lag effect persisting from the week before conception through the 6th week of gestation.
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The effects of fine particulate matter (PM) on de novo hypertensive disorders of pregnancy (HDP) were inconsistent during the first and second trimesters. This study aimed to assess the trimester-specific effects of PM and PM prior to diagnosis of de novo HDP. The exposure of fine PM was predicted by satellite remote sensing data according to maternal residential addresses.

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Objective: To evaluate HPV-negative cervical high-grade precancerous lesions or cancer in China.

Methods: Histologically confirmed cervical intraepithelial neoplasia grade 2 or worse (CIN2+) were searched in a multicentric clinical study. All patients underwent cobas HPV testing, liquid-based cytology, DNA ploidy analysis, and colposcopy-guided biopsy.

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Background: Predicting birth weight and identifying its risk factors are clinically important. This study aims to use interpretable machine learning to predict birth weight and identity important predictors.

Methods: This prospective cohort study was conducted in Tongzhou Maternal and Child Health Care Hospital of Beijing, China, recruiting pregnant women between June 2018 and February 2019.

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Effectively identifying high-risk patients with de novo hypertensive disorder of pregnancy (HDP) is required to enable timely intervention and to reduce adverse maternal and perinatal outcomes. Electronic medical record of pregnant women with de novo HDP were extracted from a birth cohort in Beijing, China. The adverse outcomes included maternal and fetal morbidities, mortality, or any other adverse complications.

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Optimal Vitamin D (VitD) status and thyroid function are essential for pregnant women. This study aimed to explore associations between dynamic VitD status and thyroid function parameters in each trimester and throughout the pregnancy period. Information on all 8828 eligible participants was extracted from the Peking University Retrospective Birth Cohort in Tongzhou.

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Article Synopsis
  • The study aimed to explore the link between first-trimester gestational weight gain (GWG) and the risk of hypertensive disorders of pregnancy (HDP), considering various BMI categories.
  • *The analysis involved 17,901 pregnant women and found that higher early GWG class was significantly associated with increased risk of HDP, with risk ratios ranging from 1.42 to 4.62 across different GWG categories.
  • *Mean arterial pressure (MAP) measured in early pregnancy partially mediated the relationship between GWG and HDP, and the combination of early GWG and MAP improved the predictive capacity for identifying women at risk of HDP.
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