Publications by authors named "Helia Samani"
Infected macrophages transition into aerobic glycolysis, a metabolic program crucial for control of bacterial infection. However, antimicrobial mechanisms supported by aerobic glycolysis are unclear. Methylglyoxal is a highly toxic aldehyde that modifies proteins and DNA and is produced as a side-product of glycolysis.
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- Tuberculosis (TB) affects people differently, and regular lab mice don't show this variety in their responses to the disease.
- Researchers studied 19 types of wild mice from different places to see how well they fought off TB, finding that certain immune cells help control the infection better.
- They discovered a unique group of neutrophils in some mice that didn't fight TB effectively, even though most mice with lots of neutrophils had trouble with the infection.