Publications by authors named "Heli Mattila"
Accumulation of amyloid-β is a key neuropathological feature in brain of Alzheimer's disease patients. Alterations in cerebral haemodynamics, such as arterial impulse propagation driving the (peri)vascular CSF flux, predict future Alzheimer's disease progression. We now present a non-invasive method to quantify the three-dimensional propagation of cardiovascular impulses in human brain using ultrafast 10 Hz magnetic resonance encephalography.
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- Identifying biomarkers that reflect early changes in Alzheimer's disease (AD) can enhance detection and lead to better interventions.* -
- The study analyzed blood oxygen level-dependent (BOLD) signal variability in 80 AD patients and 90 controls, revealing increased variability in AD patients compared to controls.* -
- This increased BOLD signal variability is linked to cardiovascular brain pulsations, explaining how it affects cerebral perfusion and ultimately relates to impaired glymphatic clearance in AD.*