Distribution of CPP-Protein Complexes in Freshly Resected Human Tissue Material.

Interest in cell-penetrating peptides (CPPs) as delivery agents has fuelled a large number of studies conducted on cultured cells and in mice. However, only a few studies have been devoted to the behaviour of CPPs in human tissues. Therefore, we performed ex vivo tissue-dipping experiments where we studied the distribution of CPP-protein complexes in samples of freshly harvested human tissue material.

Thymidine phosphorylase as a prognostic factor in renal cell carcinoma.

The purpose of the current study was to clarify further the clinicopathologic significance of thymidine phosphorylase (TP) expression in renal cell carcinoma (RCC). TP expression was evaluated with immunohistochemistry assays using monoclonal anti-TP antibody in formalin-fixed, paraffin-embedded archived specimens of 70 patients with radically operated nonmetastatic RCC (M0 by TNM classification). Semiquantitative analysis, using a scoring system for staining pattern and staining intensity was used.