Impact of bedding volume on physiological and behavioural parameters in laboratory mice.

The standard housing temperature in animal facilities is substantially below the lower critical temperature of mice. This does not only endanger animal welfare, it can also jeopardize scientific research as cold stress has a major impact on mouse physiology. There is some evidence that deep bedding, comparable to nesting material, can help mice to reduce heat loss.

Effects of different blood collection methods on indicators of welfare in mice.

Blood collection is a common experimental procedure for which there are many different methods, each with its own advantages and disadvantages. Researchers should use methods that minimize pain, suffering, distress and lasting harm to animals while meeting study requirements. The authors evaluated stress, activity and tissue damage in BALB/cO1aHsd mice after collecting blood using one of six methods: retrobulbar bleeding with thin or thick capillaries, tail vein bleeding, saphenous vein bleeding, facial vein bleeding or jugular vein bleeding.

The amount of cage bedding preferred by female BALB/c and C57BL/6 mice.

In order to improve the welfare of laboratory mice, a number of different environmental enrichment strategies have been developed to provide opportunities for mice to engage in naturalistic behaviors. Providing sufficient cage bedding for mice to use as a burrowing substrate could be considered an environmental enrichment strategy, but few studies have considered the welfare aspects of cage bedding amount. The authors compared the preferences of group-housed female BALB/c and C57BL/6 mice for three different volumes of cage bedding (0.