Publications by authors named "Helene Vallin"
Purpose: Septic shock is associated in some patients with a profound immunosuppression. We hypothesized that GM-CSF would reduce the occurrence of ICU-acquired infections in immunosuppressed septic patients.
Methods: Randomized double-blind trial conducted between 2015 and 2018.
Article Synopsis
- ICU-acquired infections (IAI) increase hospital stays, costs, and mortality, and current biomarkers aren’t effective in identifying patients at risk.
- A study analyzed the mRNA expression of two biomarkers, CD74 and IL10, in 725 ICU patients to see if they could predict IAI occurrence.
- Results indicated that higher levels of CD74 and IL10 were significantly associated with a higher risk of developing IAI, suggesting they could be useful for identifying at-risk patients.
Article Synopsis
- Sepsis triggers a systemic inflammatory response to infection, impacting both innate and adaptive immune functions, primarily through neutrophils which act as the initial defense.
- A transcriptomic study on neutrophils from septic shock patients identified 364 up-regulated and 328 down-regulated genes, with CD177 mRNA showing the greatest increase, later confirmed at the protein level.
- The study found that septic neutrophils had higher CD177 expression, but this was not linked to immunosuppression, while its up-regulation was inversely associated with CD10 expression, highlighting CD177's potential dual role in neutrophil maturation and chemotaxis during sepsis.
Background: Chemokine (C-X3-C motif) receptor 1 (CX3CR1) was identified as the most differentially expressed gene between survivors and non-survivors in two independent cohorts of septic shock patients and was proposed as a marker of sepsis-induced immunosuppression. Whether such a biomarker is associated with mortality in the heterogeneous group of critically ill patients is unknown. The primary objective of this study was to evaluate the association between CX3CR1 messenger RNA (mRNA) expression and mortality in intensive care unit (ICU) patients.
View Article and Find Full Text PDFBackground: As early and appropriate care of severe septic patients is associated with better outcome, understanding of the very first events in the disease process is needed. Pan-genomic analyses offer an interesting opportunity to study global genomic response within the very first hours after sepsis. The objective of this study was to investigate the systemic genomic response in severe intensive care unit (ICU) patients and determine whether patterns of gene expression could be associated with clinical severity evaluated by the severity score.
View Article and Find Full Text PDFPurpose: Adjunctive immunoadjuvant therapies are now proposed in the treatment of septic patients that develop immune dysfunctions. However, a prerequisite is to identify patients at high risk of death that would benefit from such therapy. Knowing that rhIL-7 is a putative candidate for septic shock treatment, we evaluated the association between increased plasmatic level of soluble CD127 (sCD127, IL-7 receptor alpha chain) and mortality after septic shock.
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