Publications by authors named "Helene Ternet-Fontebasso"
The balance between detoxification and toxicity is linked to enzymes of the drug metabolism Phase I (cytochrome P450 or oxidoreductases) and phase II conjugating enzymes (such as the UGTs). After the reduction of quinones, the product of the reaction, the quinols-if not conjugated-re-oxidizes spontaneously to form the substrate quinone with the concomitant production of the toxic reactive oxygen species (ROS). Herein, we documented the modulation of the toxicity of the quinone menadione on a genetically modified neuroblastoma model cell line that expresses both the quinone oxidoreductase 2 (NQO2, E.
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- Dunnione, derived from Gesneriaceae leaves, shows potential as a substrate for quinone-reductases linked to its antimalarial effects.
- The research assessed derivatives of Dunnione for their antiplasmodial and antimalarial properties, revealing that most had weak to moderate activity, with the most effective showing an IC value of 0.58 µM.
- In vivo tests on a murine model indicated moderate activity at a dose five times greater than chloroquine, suggesting a need for further refinements to enhance efficacy against parasitized red blood cells.
Article Synopsis
- Nanocrystalline calcium phosphate apatites are special minerals that make up hard parts of our body and can now be made in labs for medical uses.
- Recent improvements have helped scientists understand these materials better, especially how they can help with cancer diagnosis and treatment.
- Researchers have created tiny glowing particles to help see cancer cells and developed a new way to deliver cancer-fighting drugs more effectively using gel and microsphere combinations that release medicine over time.