Publications by authors named "Helene Solhi"
In connection with previous work on V-shaped polycyclic thiazolo[5,4-]quinazolin-9-one and [5,4-]quinazoline derivatives that can modulate the activity of various kinases, the synthesis of straight thiazole-fused [4,5-] or [5,4-]quinazolin-8-ones and quinazoline derivatives hitherto undescribed was envisioned. An innovative protocol allowed to obtain the target structures. The synthesis of inverted thiazolo[4,5-] and [5,4-]quinazolin-8-one derivatives was also explored with the aim of comparing biological results.
View Article and Find Full Text PDFIn this paper, we report a short and efficient synthesis of novel -arylbenzo[]quinazoline-2-amines. We have prepared a focused library of nineteen representative examples which have been submitted to cytotoxicity assays against a representative panel of eight cancer cell lines and several molecules gave attractive results in this area.
View Article and Find Full Text PDFArticle Synopsis
- Lung cancer is a leading cause of cancer-related deaths, necessitating advanced preclinical models to explore new treatments based on tumor genetics.
- Researchers developed and characterized cell lines and mouse models for non-small cell lung cancer (NSCLC) to monitor tumor growth and treatment response effectively.
- The study found that combining osimertinib and bevacizumab improves treatment outcomes for EGFR-mutated tumors, while adding afatinib helps inhibit tumor growth during treatment resistance, demonstrating the models’ utility for testing new therapies and understanding resistance mechanisms.
Article Synopsis
- Three series of CLK1 inhibitors were designed, synthesized, and tested against CLKs and DYRK1A kinases for their effectiveness in killing cancer cells.
- The research focused on modifying part of the chemical structure, leading to the discovery of a new derivative that is highly effective with low inhibition concentrations for both CLK1 and DYRK1A.
- A comprehensive analysis showed that this new compound is highly selective for CLK inhibition, indicating its potential for developing targeted cancer treatments.
A small library of new piperidine-triazole hybrids with 3-aryl isoxazole side chains has been designed and synthesized. Their cytotoxicity against a panel of seven cancer cell lines has been established. For the most promising compound, an IC value of 3.
View Article and Find Full Text PDFWe describe in this paper the synthesis of a novel series of anilino-2-quinazoline derivatives. These compounds have been screened against a panel of eight mammalian kinases and in parallel they were tested for cytotoxicity on a representative panel of seven cancer cell lines. One of them (DB18) has been found to be a very potent inhibitor of human "CDC2-like kinases" CLK1, CLK2 and CLK4, with IC values in the 10-30 nM range.
View Article and Find Full Text PDFObjective: The aim of this work was to determine the relevance of Choukroun's platelet-rich fibrin (PRF) in dental implantology by determining the in vitro effects of soluble factors released by PRF clot. We used 3 different cell lines implicated in dental implantology: osteoblast, keratinocyte, and fibroblast.
Methods: Cellular viability, cell proliferation, and gene expression were analyzed using PRF conditioned medium.