Publications by authors named "Helene Lemenager"
Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this bacterium to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin, in vivo, for the modulation of cutaneous sebum production.
View Article and Find Full Text PDFHuman adipose-derived stem/stromal cells (hASCs) can differentiate into specialized cell types and thereby contribute to tissue regeneration. As such, hASCs have drawn increasing attention in cell therapy and regenerative medicine, not to mention the ease to isolate them from donors. Culture conditions are critical for expanding hASCs while maintaining optimal therapeutic capabilities.
View Article and Find Full Text PDFArticle Synopsis
- Researchers created a 3-D model of human adipose tissue (AT) that mimics the natural structure found in the body, addressing issues with standard culture methods.
- The model consists of spheroids made from human adipose progenitors, featuring organized endothelial networks that support mature adipocytes with lipid vacuoles.
- When these spheroids were transplanted into immune-deficient mice, they successfully integrated with the mice's circulatory system, maintaining human adipocytes, indicating the model's potential for studying human AT.