Publications by authors named "Helene Lehors"
Article Synopsis
- A study in southern France explored the link between exposure to endocrine-disrupting chemicals (EDCs) and isolated hypospadias in children, finding a significant association between increased fetal exposure to EDCs and the occurrence of this condition.
- The research involved 408 children with isolated hypospadias and 302 healthy boys, assessing parental occupational and environmental exposures to EDCs using questionnaires and job-exposure matrices, particularly focusing on the period during which genital differentiation occurs.
- Results indicated that fetal exposure to EDCs was much higher in hypospadias cases (40%) compared to controls (17%), with mothers in specific occupations like cleaning and hairdressing showing increased exposure levels.
Background: Androgens are critical in male external genital development. Alterations in the androgen sensitivity pathway have been identified in severely undermasculinized boys, and mutations of the androgen receptor gene (AR) are usually found in partial or complete androgen insensitivity syndrome (AIS).
Objective: The aim of this study was to determine whether even the most minor forms of isolated hypospadias are associated with AR mutations and thus whether all types of hypospadias warrant molecular analysis of the AR.