Effective control of lung infection despite tertiary lymphoid structure disorganisation.

Background: Tertiary lymphoid structures (TLS) are triggered by persistent bronchopulmonary infection with , but their roles remain elusive. The present study sought to examine the effects of B- and/or T-cell depletion on infection and TLS development (lymphoid neogenesis) in mice.

Methods: C57Bl/6 mice were pre-treated with 1) an anti-CD20 monoclonal antibody (mAb) (B-cell depletion) or 2) an anti-CD4 and/or an anti-CD8 mAb (T-cell depletion) or 3) a combination of anti-CD20, anti-CD4 and anti-CD8 mAbs (combined B- and T-cell depletion) or 4) isotype control mAbs.

A Telemedicine Intervention to Ensure the Correct Usage of Inhaler Devices.

Chronic obstructive pulmonary disease and asthma patients' use of inhalers is error prone. This study evaluated telemedicine to improve the use of inhalers. Prospective, single-center pilot study in 50 patients with long-term prescription of inhaled medicine and ongoing home health care visits.