Publications by authors named "Helene Garcon"
Article Synopsis
- Human genetic studies often lack diversity, which limits understanding of disease causes and health disparities.
- The Department of Veterans Affairs Million Veteran Program analyzed data from a diverse group of 635,969 veterans, revealing 13,672 genomic risk loci, with significant findings particularly from non-European populations.
- The research identified causal variants across 613 traits, showing that genetic similarities exist across populations and emphasizing the importance of including underrepresented groups in genetic research.
Genome-wide association studies (GWAS) have underrepresented individuals from non-European populations, impeding progress in characterizing the genetic architecture and consequences of health and disease traits. To address this, we present a population-stratified phenome-wide GWAS followed by a multi-population meta-analysis for 2,068 traits derived from electronic health records of 635,969 participants in the Million Veteran Program (MVP), a longitudinal cohort study of diverse U.S.
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- Researchers studied the rs35705950-T genetic variant to see how it affects the risk of severe outcomes in COVID-19 patients, particularly in the Million Veteran Program (MVP) participants.
- The study found that those with the rs35705950-T allele had fewer hospitalizations due to COVID-19 but did not show significant differences in overall positivity rates for the virus.
- The variant was linked to reduced rates of post-COVID-19 pneumonia among individuals of European ancestry, suggesting potential protective effects against certain complications of the disease.
Article Synopsis
- Sickle cell trait (SCT) affects millions in the US, especially among African and Hispanic populations, but its link to COVID-19 remains uncertain.* -
- The study analyzed data from the Million Veteran Program, comparing 2,729 SCT-positive individuals, 353 of whom had COVID-19, to SCT-negative individuals to understand COVID-19 outcomes.* -
- Results showed that SCT is associated with higher COVID-19 mortality among individuals of African ancestry and linked to various chronic health conditions before the pandemic.*
Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted Mendelian randomization analyses, deriving genetic instruments based on transcriptomic and proteomic data for 1,263 actionable proteins that are targeted by approved drugs or in clinical phase of drug development. Using summary statistics from the Host Genetics Initiative and the Million Veteran Program, we studied 7,554 patients hospitalized with COVID-19 and >1 million controls.
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