Publications by authors named "Helene Cox"
Article Synopsis
- The CRMP family proteins, particularly CRMP5/DPYSL5, are crucial for neuronal development, influencing dendrite structure and axonal pathfinding, and their function is linked to neurotrophic factors.
- Recent research identified mutations in the DPYSL5 gene in nine individuals with brain malformations and varying degrees of intellectual disability, with two specific mutations being the focus.
- The identified mutations disrupt the protein's ability to interact with key neuronal proteins, leading to impaired dendritic growth and contributing to abnormal brain development, highlighting DPYSL5's role in neurodevelopmental disorders.
