Publications by authors named "Helene Auble"
Article Synopsis
- Transcatheter arterial chemoembolisation (TACE) is used for treating liver cancer patients who can't undergo curative therapies; this study compared TACE alone with TACE combined with external conformal radiotherapy (CRT).
- The trial involved 120 participants, mostly older males with alcohol-related liver issues, and aimed to assess liver progression-free survival (PFS) over 12 and 18 months.
- Results indicated that while the combined treatment (TACE + CRT) showed better local control, it did not significantly improve PFS or overall survival compared to TACE alone, and led to more serious liver-related side effects.
T cell exclusion causes resistance to cancer immunotherapies via immune checkpoint blockade (ICB). Myeloid cells contribute to resistance by expressing signal regulatory protein-α (SIRPα), an inhibitory membrane receptor that interacts with ubiquitous receptor CD47 to control macrophage phagocytosis in the tumor microenvironment. Although CD47/SIRPα-targeting drugs have been assessed in preclinical models, the therapeutic benefit of selectively blocking SIRPα, and not SIRPγ/CD47, in humans remains unknown.
View Article and Find Full Text PDFBackground & Aims: In most autoimmune disorders, crosstalk of B cells and CD4 T cells results in the accumulation of autoantibodies. In autoimmune hepatitis (AIH), the presence of anti-soluble liver antigen (SLA) autoantibodies is associated with reduced overall survival, but the associated autoreactive CD4 T cells have not yet been characterised. Herein, we isolated and deeply characterised SLA-specific CD4 T cells in patients with AIH.
View Article and Find Full Text PDFAutoimmune hepatitis (AIH) is a rare disease characterized by an immune attack of the liver. This study consists of a comprehensive analysis of immune alterations related to AIH at diagnosis, and during remission phase under treatment. A total of 37 major lymphocyte populations were analyzed from the peripheral blood of new-onset AIH patients (AIHn; n = 14), AIH patients with controlled disease (n = 11), and healthy subjects (n = 14).
View Article and Find Full Text PDFBackground & Aims: In patients with cirrhosis, the risk of hepatocellular carcinoma (HCC) depends upon age, gender and the etiology of liver disease. Few studies are available in Caucasian patients with alcoholic or metabolic cirrhosis without viral hepatitis.
Methods: Cross-sectional clinical data from 905 HCV- and HBV-negative Caucasian patients with alcoholic or metabolic cirrhosis were prospectively collected in four French centres.