Systemic mastocytosis (SM) is a disorder that can cause severe allergic reactions, especially triggered by insect stings, and diagnosing indolent SM without skin symptoms is not uncommon.*
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Venom immunotherapy (VIT) effectively reduces the risk of future reactions in patients with indolent SM, and it's crucial to personalize this treatment by distinguishing between true venom allergies and cross-reactivity.*
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In a case study of a man who experienced anaphylaxis after wasp stings, molecular diagnosis did not clarify his allergies, so a CAP-inhibition assay was necessary, emphasizing the need for precise assessments in hymenoptera venom allergy.*