A Novel Look at Mechanisms and Applications of Xanthohumol (XN) in Dermatology and Cosmetology.

Xanthohumol (XN), representing the group of chalcones, is a hydroxyl and superoxide free radical scavenger. It also has antimicrobial properties, showing antibacterial activity against Staphylococcus aureus, Staphylococcus pyogenes, Staphylococcus epidermidis and Propionibacterium acnes. XN exerts an inhibitory effect on tyrosinase (it hinders the oxidation of l-tyrosine and l-DOPA).

The Impact of Carboxytherapy and Treatments Combining Carboxytherapy and Selected Chemical Peels on Vascular and Pigmentary Components of the Dark Circles.

Objective: Particular attention is given to the enhancement of melanin-related pigmentation (dark circles, photoaging) and vascular circles, which are commonly located in the tear trough. The objective of the study is to provide an objective evaluation of the impact of carboxytherapy and the treatment regimen combining carboxytherapy with lactobionic acid (20%, pH 2.1) or ferulic acid (14%, pH 4.

The assessment of the impact of carboxytherapy and selected chemical peels on cosmetic defects and signs of aging of skin around eyes.

Objective: The purpose of this study was to assess changes in skin elasticity and other skin defects related to the aging of skin around eyes following the use of combination treatment carboxytherapy and chemical peels (ferulic acid combined with ascorbic acid, lactobionic acid).

Material And Methods: A total of 39 Caucasian patients were subjected to a series of five combination carboxytherapy and chemical peels treatments at weekly intervals. The Cutometer device was used to objectively measure skin elasticity.

Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters.

Background: The application of polyhydroxy acids and alpha-hydroxy acids to the skin is often used in cosmetology. To enhance the effect of gluconolactone chemical peeling, a combined method including water-oxygen oxybrasion or microneedle mesotherapy can be used.

Objectives: To evaluate skin parameters such as hydration, sebum, pH and TEWL after application of a 10% gluconolactone chemical peel in combination with oxybrasion and microneedling.

Evaluation of the effects of 10% and 30% gluconolactone chemical peel on sebum, pH, and TEWL.

Background: Gluconolactone (GLA) exhibits antioxidant and moisturizing effects. It also presents soothing effects, protects elastin fibers from UV-induced degradation, and improves the function of the skin barrier.

Aims: Evaluation of skin parameters such as pH, transepidermal water loss (TEWL), sebum levels before, during, and after a series of applications of 10% and 30% GLA chemical peel in a split-face model.

Objective, measurable assessment of the elasticity of the skin around the eyes following the carboxytherapy treatment.

Background: Carboxytherapy is one of the most popular procedures used in dermatology. The treatments are known to be minimally invasive and highly effective for various skin disorders. Therefore, the research carried out in the paper is purposeful and addresses an important area of aesthetic therapies.

The correlation between the severity of symptoms and the thickness of the fat fold in cellulite-affected areas-A pilot study.

Objective: The aim of the study was to assess the correlation between the cellulite severity and the thickness of the fat fold.

Material And Methods: The study comprised 62 women aged 22 to 26 years. A palpation and visual evaluation of cellulite severity was performed on the basis of the Nurnberger and Muller classification, and the thickness of adipose tissue (fatty tissue) was measured with the use of a skinfold caliper.

Ferulic acid - A novel topical agent in reducing signs of photoaging.

Continuous production of reactive oxygen species, induced by UV radiation, is one of the main mechanisms contributing to skin photoaging. Therefore, the use of novel superior antioxidants, which ferulic acid belongs to, is an innovative treatment option. The aim of this study was to evaluate the effect of 14% ferulic acid peel on skin hydration, topography, the level of melanin, and the severity of erythema, in people with skin photoaging symptoms.

Two superior antioxidants: Ferulic acid and ascorbic acid in reducing signs of photoaging-A split-face comparative study.

The assessment of the signs of photoaging in mexametric (melanin and erythema index), corneometric (hydration level), and cutometric (elasticity) examination after the treatment with ascorbic acid and ferulic acid. This study was conducted in a group of 20 women aged 39-61 (mean age 54), with Fitzpatrick skin types II and III. The study included a series of eight treatments performed once a week.

Efficacy of fractional laser, radiofrequency and IPL rejuvenation of periorbital region.

The purpose of this study was to assess skin elasticity, the reduction in the number and the depth of wrinkles and changes in the other skin defects (bags under the eyes, dark circles under the eyes, skin hyperpigmentation in the ageing eye area following the use of non-ablative fractional laser, bipolar radiofrequency and intense pulsed light). Moreover, the study was also comparison which device brought better results than the others. This study included 71 patients (66 women, 5 men), aged 33-63 years (the average age was 45.

Shikimic acid in the light of current knowledge.

Shikimic acid (SA) has been mainly used in the pharmaceutical industry for production of drugs, however, recently it has also appeared in the world of cosmetics. So far, there have not been many publications on cosmetics containing SA or research studies on the compound, especially those that would involve testing cosmetic products on subjects. The main source of SA is star anise.

Corneometric evaluation of skin moisture after application of 10% and 30% gluconolactone.

Background: Dry skin, caused by improper care or genetic conditions, can affect people of all ages. Skin hydration is determined its lipid content, which inhibits water loss from the epidermis, as well as other substances such as polyhydroxy acids and gluconolactone that can bind water. The aim of this study was to evaluate skin hydration after the application of 10% and 30% gluconolactone solution in a split face model.

How has the pandemic lockdown changed our daily facial skincare habits?

Background: During the COVID-19 pandemic, Poland implemented widespread closure of beauty and cosmetic services to control the virus spread.

Aims: The aim of this study was to investigate the impact of the SARS-CoV-2 pandemic on home face care of women and to analyze changes that have occurred in their daily habits.

Patients/methods: An online survey was completed by 412 women living in Poland during the spring lockdown.

The influence of topical 5% tranexamic acid at pH 2.38 with and without corundum microdermabrasion on pigmentation and skin surface lipids.

Tranexamic acid (TA) has anti-hemorrhagic effects; however, oral administration has been found to decrease hyperpigmentation. The aim of the work was to compare the effects of treatment with 5% tranexamic acid in combination with corundum microdermabrasion on skin pigmentation, redness, pH, transepidermal water loss (TEWL), sebum level and hydration of back surface and dorsal surface of the hand skin. Six treatments were performed every week on the back surface and both dorsal surfaces of the hands of 12 subjects.

The eye area as the most difficult area of activity for esthetic treatment.

Eyes area is of high importance in esthetic dermatology. This area is one of the most difficult for procedures. Skillful treatment can significantly improve the quality of patients' life.

The effectiveness of ferulic acid and microneedling in reducing signs of photoaging: A split-face comparative study.

Photoaging is closely related to ultraviolet-induced oxidative stress. Ferulic acid is a plant-based antioxidant with antiaging activity. Combining ferulic acid peel with microneedling enhances its transdermal penetration.

Effect of oxybrasion on selected skin parameters.

Background: Oxybrasion is one of the types of microdermabrasion. This method removes a superficial epidermal layer with the use of a stream of 0.9% saline solution and compressed air.

Comparison of hair reduction by intensive pulsed light device and combined intense pulsed light with a bipolar radiofrequency.

Background: Photoepilation has become a very popular epilation procedure in esthetic and cosmetic practice. There are some types of lasers and other light sources used for epilation.

Aims: The purpose of our study was to compare an IPL device with an IPL plus RF in one device, using a within-patient, right-left controlled study design.

Comparative study of 15% trichloroacetic acid peel combined with 70% glycolic acid and 35% trichloroacetic acid peel for the treatment of photodamaged facial skin in aging women.

Background: Photoaging (extrinsic aging) is caused by environmental exposure to ultraviolet radiation. Superficial and medium-depth chemical peels with trichloroacetic acid (TCA) are performed to reduce wrinkles, hyperpigmentation, dryness, and erythema caused by photoaging process.

Aim: The aim of this study was to compare the efficacy and tolerability of 15% TCA peel against the combined 70% glycolic acid and 35% TCA for the treatment of photodamaged facial skin.

The evaluation of elasticity after nonablative radiofrequency rejuvenation.

Background: Laxity and rhytides are manifestations of photodamage on the face and chest. Nonablative radiofrequency (RF) is one of the most common procedures used for skin rejuvenation.

Aim: The aim of this study was to assess the elasticity of face and chest skin after multipolar radiofrequency.

Effects of lactobionic acid peel, aluminum oxide crystal microdermabrasion, and both procedures on skin hydration, elasticity, and transepidermal water loss.

Background: Topical applications of alpha-hydroxy acids and poly hydroxy acids in the form of peels gained popularity. To enhance the effect of these substances, aluminum oxide crystal microdermabrasion can be used in one procedure.

Aims: The assessment of skin hydration, elasticity, and TEWL after using lactobionic acid in the form of 20% peel and lactobionic acid in the form of 20% peel combined with aluminum oxide crystal microdermabrasion.

The effect of various primers improving adhesiveness of gel polish hybrids on pH, TOWL and overall nail plates condition.

Background: Hybrid manicure is now a popular method of nail care and nail art, which is associated with its durability. Unfortunately, it has an adverse effect on pH, TOWL and overall nail plates condition and has not been investigated in detail so far.

Aims: The aim of this study was to compare the pH and TOWL of the hand nails after using different primers.

The assessment of the effects of the combination of microdermabrasion and cavitation peeling in the therapy of seborrhoeic skin with visible symptoms of acne punctata.

The aim of this study was to assess objectively the effects of the combination of corundum microdermabrasion and cavitation peeling in the therapy of seborrheic skin with visible symptoms of acne punctata. The study involved a group of nine women. A series of six treatments with the combination of microdermabrasion and cavitation peeling were performed within facial skin at 10-14 days intervals.

Lactic and lactobionic acids as typically moisturizing compounds.

Background: Recently more attention has been drawn to alpha hydroxy and polyhydroxy acids (AHA and PHA) due to their excellent moisturizing and antioxidant properties. These compounds are very beneficial in terms of both cosmetic and dermatological treatments.

Objective: The aim of this study was an assessment of moisturizing properties of lactobionic and lactic acids based on available literature.

Is skin microneedling a good alternative method of various skin defects removal.

Skin microneedling accelerates the process of skin regeneration through the creation of numerous microinjuries which emerge when skin is deeply punctured with very thin needles. The whole procedure evokes various reactions which can be divided into three major phases: inflammation, proliferation, and remodeling. It activates platelet growth factors which are responsible for the stimulation of fibroblasts to produce collagen and elastin.