Antimicrobial Efficacy of L. Extracts for Dental Caries: Green Extraction Techniques and Bioactive Compounds.

Dental caries is a highly prevalent chronic condition globally. In recent years, scientists have turned to natural compounds such as plant extracts as an alternative to address concerns related to biofilm-mediated disease transmission, increasing bacterial resistance, and the adverse impacts of antibiotics. Consequently, this study investigated the antimicrobial properties of ethanolic, hydroethanolic, and aqueous extracts of L.

Medicinal Chemistry of Antisense Oligonucleotides for Therapeutic Use in SARS-CoV-2: Design Strategies and Challenges for Targeted Delivery.

Background: The evolution of novel Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) strains with greater degrees of infectivity, resistance to vaccine-induced acquired immunity, and more severe morbidity have contributed to the recent spread of COVID-19. In light of this, novel therapeutic alternatives with improved effectiveness and fewer side effects have become a necessity. Despite many new or repurposed antiviral agents recommended for Coronavirus disease (COVID-19) therapy, this objective remains unfulfilled.