Publications by authors named "Helena M Gazolla"
Decreased serum inhibin B/FSH ratio as a marker of Sertoli cell function in male survivors after chemotherapy in childhood and adolescence.
Maria Alice Neves Bordallo Marília Martins Guimarães Cencita Hosanha C N Pessoa Maria Kadma Carriço Trude Dimetz Helena Mussi Gazolla
J Pediatr Endocrinol Metab
June 2004
Article Synopsis
- The study investigates the impact of chemotherapy on male gonadal function in cancer survivors by analyzing the inhibin B/FSH ratio, a potential marker for seminiferous tubule function.
- It includes 21 male survivors of Hodgkin's disease treated in childhood, compared against 20 healthy young men as controls, focusing on serum levels of inhibin B, FSH, LH, testosterone, and semen analysis.
- Results show significant gonadal dysfunction in cancer survivors, indicated by lower testicular volume, abnormal sperm analysis, and a higher FSH level, highlighting the need to consider inhibin B levels alongside FSH for assessing testicular damage post-chemotherapy.
The aim of this study was to determine serum insulin, insulin-like growth factor-I (IGF-I) and its binding proteins (IGFBP-1 and IGFBP-3) levels and their relationship with androgen levels and ovarian structure in 23 girls with premature pubarche (PP). Fasting levels of testosterone, dehydroepiandrosterone (DHEA) and its sulfate (DHEAS), androstenedione (delta4A), sex hormone binding globulin (SHBG), glucose (G), insulin (I), IGF-I, IGFBP-1, IGFBP-3 were measured. Androgens or steroid hormone levels > 3 SD of normal postpubertal levels were considered as an exaggerated response to the ACTH test.
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