Publications by authors named "Helena Lin"
Cell Death Dis
November 2022
Article Synopsis
- Alzheimer's disease (AD) is the leading type of dementia, and its connection with severe muscle loss (sarcopenia) is not fully understood.
- Researchers created a mouse model, TgAPP, that expresses a mutant form of a gene related to AD specifically in skeletal muscles, revealing symptoms similar to sarcopenia and AD-related brain issues.
- The study suggests that the expression of this gene in muscles leads to harmful inflammatory responses and disrupts growth factors, potentially linking muscle health with brain function and contributing to the development of AD.
