Effect of antiprogesterone mifepristone followed by misoprostol on circulating leptin in early pregnancy.

Background: To study the role of progesterone (P4) in the regulation of circulating leptin in early human pregnancy, we measured the levels of leptin before and after administration of the antiprogestin mifepristone, followed by misoprostol in early pregnancy.

Methods: Thirty-four women requesting termination of pregnancy, with < or =63 days of amenorrhea, received 200 mg of mifepristone on day 0, followed by either oral or vaginal administration of 0.8 mg of misoprostol on day 2.

WHO multinational study of three misoprostol regimens after mifepristone for early medical abortion.

Objectives: To compare the side effect profiles of regimens of oral and vaginal administration of misoprostol after a single oral dose of 200 mg of mifepristone and to investigate patients' perceptions of medical abortion.

Design: Double-blind, randomised controlled trial.

Setting: Fifteen gynaecological clinics in 11 countries.

Differential kinetics of serum and cervical insulin-like growth factor-binding protein-1 during mifepristone-misoprostol-induced medical termination of early pregnancy.

The kinetics of cervical and circulating phosphoisoforms of insulin-like growth factor-binding protein-1 (IGFBP-1) in normal and pathological early pregnancy are not well known. We investigated the profiles of IGFBP-1 in serum and in cervical secretion during medical termination of early pregnancy. Sixteen women requesting termination of pregnancy, with <63 days of amenorrhoea, received 200 mg of mifepristone on day 0, followed by either oral or vaginal administration of 0.

WHO multinational study of three misoprostol regimens after mifepristone for early medical abortion. I: Efficacy.

Objectives: To compare the efficacy of oral and vaginal administration of misoprostol after a single oral dose of 200 mg of mifepristone and to investigate whether the efficacy can be improved and the duration of bleeding shortened by continuing oral misoprostol for one week.

Design: Double blind, randomised controlled trial.

Setting: Fifteen gynaecological clinics in 11 countries.

Termination of pregnancy with mifepristone and prostaglandin suppresses transiently circulating glucocorticoid bioactivity.

Mifepristone is a potent antiglucocorticoid, the administration of which results in a dose-dependent activation of the hypothalamic-pituitary-adrenal axis. However, the net effect of this compound on circulating glucocorticoid activity is not known. We have used a recombinant cell bioassay to study glucocorticoid bioactivity (GBA), measured directly from serum, in 18 women undergoing medical termination of an early pregnancy with 200 mg mifepristone, followed by 0.

The kinetics of serum hCG and progesterone in response to oral and vaginal administration of misoprostol during medical termination of early pregnancy.

Background: Misoprostol is widely used in combination with mifepristone for medical termination of pregnancy. We studied the endocrine parameters of trophoblast function during medical termination of early pregnancy using mifepristone in combination with oral or vaginal misoprostol. The effect of prolonged misoprostol administration was also examined.

Users' perspectives on medical abortion in Finland.

The objective of this study was to determine the reasons for choosing the medical instead of surgical method for the termination of early pregnancy, and to evaluate the experience and the level of satisfaction with the medical method among women in Helsinki who participated in a multinational efficacy study of medical abortion. The study respondents consisted of 123 women with less than 9 weeks gestation, undergoing medical abortion with mifepristone 200 mg orally followed 36 h to 48 h later by misoprostol 0.8 mg orally or vaginally.