Publications by authors named "Helena Hagner Gram"
The role of MDC1 in the DNA damage response has been extensively studied; however, its impact on other cellular processes is not well understood. Here, we describe the role of MDC1 in transcription as a regulator of RNA polymerase II (RNAPII). Depletion of MDC1 causes a genome-wide reduction in the abundance of actively engaged RNAPII elongation complexes throughout the gene body of protein-encoding genes under unperturbed conditions.
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- Mutations in the lamin A/C gene cause diseases like Hutchinson Gilford progeria syndrome (HGPS) and are linked to various cancers, yet their mechanisms are not well understood.
- Research shows that lamin A/C-deficient mouse cells and human HGPS cells have low NAD+ levels and mitochondrial problems, leading to reduced mitochondrial function and energy production.
- The study identifies that lamin A/C influences mitochondrial health by affecting the recruitment of PGC1α and the NAMPT-NAD+ pathway, illuminating potential connections between laminopathies and aging.