This study investigates the effectiveness of adalimumab, an anti-TNFα agent, for treating childhood noninfectious uveitis (NIU) and aims to establish a therapeutic range for its trough levels.
The research involved analyzing serum trough levels in 36 children treated with adalimumab, finding that those who fully responded had higher levels (average 11.8 μg/mL) than partial or non-responders (average 9.2 μg/mL).
The suggested therapeutic range for optimal clinical effects was determined to be between 9.6 to 13 μg/mL, highlighting the importance of therapeutic drug monitoring to enhance treatment outcomes for these pediatric patients.