Publications by authors named "Helena Dorado"
Autosomal dominant optic atrophy (ADOA) is a rare progressive disease mainly caused by mutations in , a nuclear gene encoding for a mitochondrial protein that plays an essential role in mitochondrial dynamics, cell survival, oxidative phosphorylation, and mtDNA maintenance. ADOA is characterized by the degeneration of retinal ganglion cells (RGCs). This causes visual loss, which can lead to legal blindness in many cases.
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- The study investigates the impact of polystyrene (PS) nanoplastics on the larvae of Chironomus riparius, focusing on DNA damage and gene expression related to various stress responses after 24-hour exposure to environmentally relevant doses of PS NPs.
- Results indicated a significant genotoxic effect, evidenced by increased DNA strand breaks and decreased expression of genes responsible for DNA repair and other crucial biological processes like cellular stress, development, and oxygen transport.
- The findings suggest that PS NPs may disrupt the endocrine system and inhibit critical physiological functions in these aquatic organisms, highlighting potential ecological risks stemming from plastic pollution in water bodies.