Publications by authors named "Helen Y A Kraak"
Tissue Eng Part A
October 2012
Article Synopsis
- The study examined how the timing of releasing growth factors BMP-2 and VEGF affects bone formation in a large-animal model using Beagle dogs.
- PLGA microparticles provided sustained release while rapidly degrading gelatin enabled fast release of the growth factors, both combined with biphasic calcium phosphate scaffolds for implantation.
- The findings revealed that faster BMP-2 release significantly enhanced ectopic bone formation, but the timing didn't lead to notable differences at the orthotopic site, indicating the importance of BMP-2 timing over VEGF influence.
