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Publications by authors named "Helen Tinwell"

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Synopsis of recent research by authors named "Helen Tinwell"

  • - Helen Tinwell's recent research focuses on assessing the neurodevelopmental impacts of thyroid hormone imbalance, particularly through innovative testing strategies such as the Thyroid Function-Related Neurodevelopmental Toxicity Testing and Assessment Scheme (Thyroid-NDT-TAS) aimed at meeting European Endocrine Disruptor Criteria.
  • - Tinwell emphasizes utilizing the zebrafish embryo model to identify gene expression biomarkers related to developmental toxicity, notably focusing on the perturbation of the retinoic acid signaling pathway as a mechanism linked to adverse effects on mesodermal tissue development.
  • - Additional studies by Tinwell explore the development of microfluidic platforms for evaluating chemical safety in humans and the differences in thyroid hormone responses in various species, highlighting the importance of human-relevant toxicity assessments.

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