Publications by authors named "Helen Synn"
This study aimed to describe the subjective and objective results of the latissimus dorsi muscle flap and propose it as a reconstructive option for postoperative thoracic defects. A systematic search for cases with pedicle-based latissimus dorsi flaps performed after medial sternotomy was conducted, and all cases occurred between 2010 and August 2017. Preoperative, intraoperative, and postoperative factors were retrospectively analyzed and then the correlations between prognostic factors and outcomes of flap surgery were calculated.
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- The study explores how vitamin D (VD) can enhance the effectiveness of glucocorticoids (GCs) in treating acute relapses of multiple sclerosis (MS), which often lead to long-term disability.
- In vitro experiments showed that vitamin D increased the expression of glucocorticoid receptors, leading to more efficient apoptosis of T cells when combined with GCs.
- Results from two cohorts of MS patients indicated that low levels of vitamin D were linked to GC resistance, and further mechanistic studies highlighted the role of the mTOR pathway in this synergistic effect.