Publications by authors named "Helen Schaufelberger"
Background: The phenomenon of field cancerization reflects the transition of normal cells into those predisposed to cancer. Assessing the scope and intensity of this process in the colon may support risk prediction and colorectal cancer prevention.
Methods: The Swiss Epigenetic Colorectal Cancer Study (SWEPIC) study, encompassing 1111 participants for DNA methylation analysis and a subset of 84 for RNA sequencing, was employed to detect field cancerization in individuals with adenomatous polyps (AP).
Article Synopsis
- The study investigates how individual risk factors and their interactions influence the risk of two types of colorectal polyps: adenomatous polyps (AP) and serrated polyps (SP).
- Data were collected from 1,597 colonoscopy participants on various lifestyle and metabolic factors, revealing that certain factors like obesity, BMI, and diet significantly increase polyp risk, while others, like smoking, have specific associations with SP risk.
- The findings highlight that individual risk factors and their combinations are complex and vary for different polyp types, suggesting that personalized lifestyle recommendations could improve colorectal cancer prevention strategies.
Autoimmune phenomena and clinically apparent autoimmune diseases, including autoimmune hepatitis, are increasingly been reported not only after natural infection with the SARS-CoV-2 virus, but also after vaccination against it. We report the case of a 63-year old man without a history of autoimmunity or SARS-CoV-2 natural infection who experienced acute severe autoimmune-like hepatitis seven days after the first dose of the mRNA-1273 SARS-CoV-2 vaccine. Liver histology showed inflammatory portal infiltrate with interface hepatitis, lobular and centrilobular inflammation with centrilobular necrosis, in absence of fibrosis and steatosis.
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