Publications by authors named "Helen Patsea"
Article Synopsis
- Chemokines CXCL13 and CXCL9 in breast cancer may impact patient outcomes, specifically disease-free and overall survival, indicating their role in the immune microenvironment of tumors.
- Analysis of tissue samples from 557 breast cancer patients revealed that high expression of CXCL9 is generally linked to poorer survival rates, except in triple negative cases where it suggests better outcomes, while high CXCL13 correlates with improved survival in luminal-HER2 patients.
- The study highlights the importance of these chemokines as potential biomarkers for breast cancer prognosis, suggesting their relationship with tumor-infiltrating lymphocyte density and different breast cancer subtypes.
Background: Src, CDKN1B, and JAK2 play a crucial role in the coordination of cell signaling pathways. In the present study, we aim to investigate the prognostic significance of these biomarkers in HER2-positive metastatic breast cancer (MBC) patients treated with trastuzumab (T).
Methods: Formalin-fixed paraffin-embedded tumor tissue samples from 197 patients with HER2-positive MBC treated with T were retrospectively collected.
Several studies support an important role of angiogenesis in breast cancer growth and metastasis. The main objectives of the study were to investigate the immunohistochemical expression of vascular endothelial growth factor (VEGF) family ligands (VEGF-A and VEGF-C) and receptors (VEGFR1, VEGFR2 and VEGFR3) in breast cancer and their associations with clinicopathological parameters, cancer subtypes/subgroups and patient outcome. Formalin-fixed paraffin-embedded tumor tissue samples were collected from early-stage breast cancer patients treated with anthracycline-based chemotherapy within a randomized trial.
View Article and Find Full Text PDFBackground: The PI3K-AKT pathway is frequently activated in breast cancer. PIK3CA mutations are most frequently found in the helical (exon 9) and kinase (exon 20) domains of this protein. The aim of the present study was to examine the role of different types of PIK3CA mutations in combination with molecular biomarkers related to PI3K-AKT signaling in patients with early breast cancer.
View Article and Find Full Text PDFBackground: Vascular endothelial growth factor C (VEGFC) and vascular endothelial growth factor receptor 1 (VEGFR1) mRNA overexpression has recently been shown to have strong predictive and prognostic value in patients with high-risk early breast cancer undergoing adjuvant chemotherapy. The present study evaluated associations of VEGFC and VEGFR1 with human epidermal growth factor receptor 2 (HER2) and their prognostic value dependent on HER2 status.
Patients And Methods: RNA was isolated from 298 formalin-fixed paraffin-embedded tumor tissue samples from the HeCOG 10/97 (HE10/97) trial, evaluating adjuvant dose-dense sequential chemotherapy with epirubicin followed by cyclophosphamide, methotrexate and 5-fluorouracil therapy with or without paclitaxel (E-T-CMF vs.
Introduction: The authors describe a case of a patient who underwent resection of a colonic GIST mimicking a hyperplastic polyp of the descending colon.
Case Report: We report the case of a colonic Gastrointestinal Stromal Tumor (GIST) of a 55 years old male patient who was admitted to us because of rectal bleeding and altered bowel habits. Patient was initially diagnosed for hyperplastic polyps of the descending colon and thus surgical treatment was proposed.