Publications by authors named "Helen Obaro"
Transl Neurodegener
May 2023
Article Synopsis
- The study assessed the long-term safety and tolerability of sargramostim (Leukine) in five patients with Parkinson's disease (PD) over a 33-month period, examining its effects on immune response and motor functions.
- Adverse effects noted included injection-site reactions, elevated white blood cell counts, and bone pain, but no significant side effects were found during blood analyses related to long-term use.
- Results indicated stable motor function scores and increased regulatory T cell activity, suggesting that sargramostim may provide immune benefits and maintain clinical stability in PD, warranting further investigation in larger trials.
Article Synopsis
- * A Phase 1b study involving five Parkinson's patients found that a reduced dosage of 3 μg/kg/day was safer and better tolerated than a higher dose, with positive effects on immune function and a decrease in adverse events.
- * Long-term treatment at the lower dose maintained stable Movement Disorder Society-United Parkinson's Disease Rating Scale scores, indicating treatment effectiveness; however, further studies with more participants are necessary to confirm these findings.
