Design and Haemodynamic Analysis of a Novel Anchoring System for Central Venous Pressure Measurement.

Background/objective: In recent years, treatment of heart failure patients has proved to benefit from implantation of pressure sensors in the pulmonary artery (PA). While longitudinal measurement of PA pressure profoundly improves a clinician's ability to manage HF, the full potential of central venous pressure as a clinical tool has yet to be unlocked. Central venous pressure serves as a surrogate for the right atrial pressure, and thus could potentially predict a wider range of heart failure conditions.

A novel wireless implant for central venous pressure measurement: First animal experience.

Background/objective: Central venous pressure (CVP) serves as a surrogate for right atrial pressure, and thus could potentially predict a wider range of heart failure conditions. The purpose of this work is to assess CVP, through an implantable sensor incorporated with a novel anchor design, in the inferior and superior vena cava of an animal model.

Methods: Two animals (Dorset sheep) were implanted with sensors at 3 different locations: inferior vena cava (IVC), superior vena cava (SVC), and pulmonary artery (PA).

Changes in left ventricular shape and morphology in the presence of heart failure: a four-dimensional quantitative and qualitative analysis.

Purpose: The presence and progression of heart failure (HF) are associated with cardiac remodelling, defined as cellular, molecular and interstitial changes which occur after injury and manifest as changes in left ventricular (LV) size, mass, geometry and function. This research study was designed to investigate the changes to LV morphology and shape which occur in the presence of heart failure using three-dimensional (3D) modelling and analysis of cardiac-gated CT scans from both healthy individuals and patients classified with HF.

Methods: A number of quantitative and qualitative strategies were applied to cardiac CT scans of HF patients and healthy controls (n = 7) in order to analyse changes to LV size, shape and structure and to examine LV remodelling in the different classes of HF.

A Systematic Review of Outcomes After Transanal Mesorectal Resection for Rectal Cancer.

Background: Transanal mesorectal resection has been developed to facilitate minimally invasive proctectomy for rectal cancer.

Objective: The purpose of this study was to evaluate the evidence regarding technical parameters, oncological outcomes, morbidity, and mortality after transanal mesorectal resection.

Data Sources: The Cochrane Library, PubMed, and MEDLINE databases were reviewed.

Late presentation of a large Morgagni hernia in an adult.

A 57-year-old man with no medical history and comorbidities presented to the outpatient clinic with a 2-week history of increasing cough and shortness of breath following a recent viral upper respiratory tract infection. Chest X-ray showed increased mediastinal opacity. A CT scan of the thorax was performed which revealed a large right-sided diaphragmatic hernia extending across the mediastinum to the left side of the chest.

Combined enzyme replacement and haematopoietic stem cell transplantation in Hurler syndrome.

We report the long-term follow-up of successful treatment of mucopolysaccharidosis type I H (MPS IH, Hurler syndrome) with combined enzyme replacement therapy and haematopoietic progenitor stem cell transplant.

The management of mycotic femoral pseudoaneurysms in intravenous drug abusers.

Mycotic femoral pseudoaneurysms, particularly in the drug-abusing population, pose a difficult problem to the vascular surgeon. Management ranges from ligation with debridement to extra-anatomical bypass. This study reviewed the management of mycotic femoral pseudoaneurysms presenting in intravenous drug abusers to an inner city tertiary referral center.

Radiographic work-up and treatment of lower gastrointestinal bleeding.

Lower gastrointestinal hemorrhage is a common reason for hospital admission. Spontaneous cessation occurs in the majority of these patients; however, continued major bleeding is a difficult clinical problem. Emergency surgery, without prior knowledge of the bleeding site is associated with high morbidity and mortality rates.

Tetrahydrobiopterin-responsive phenylketonuria: the New South Wales experience.

Recent studies have shown that a subgroup of phenylketonuric patients respond to high doses of BH4 (20 mg/kg) by a decrease of plasma phenylalanine. A clinically significant response has been defined as a decrease in phenylalanine by more than 30% within 24 h, after a BH4 challenge. We report our experience with 37 patients diagnosed with hyperphenylalaninemia, mild, moderate, or classical Phenylketonuria (PKU) using a seven day combined BH4 and phenylalanine load.