Publications by authors named "Helen Nagels"

Article Synopsis
  • - The Cochrane review evaluates the usage of synthetic hormones dehydroepiandrosterone (DHEA) and testosterone (T) as additional treatments for improving outcomes in assisted reproductive technology (ART), particularly aiming to enhance conception rates by affecting ovarian response to hormonal stimulation.
  • - The researchers conducted a thorough search of multiple databases and selected randomized controlled trials (RCTs) comparing DHEA or T with other treatments or placebos in infertile women undergoing ART.
  • - Ultimately, the review analyzed data from 28 RCTs involving over 3,000 women and sought to determine the effectiveness and safety of these hormone treatments for enhancing reproductive success.
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Background: Infertility is a condition affecting 10% to 15% of couples of reproductive age. It is generally defined as "the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse". The treatment of infertility may involve manipulation of gametes or of the embryos themselves.

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The past three decades have seen considerable change in the understanding of clinical research methods. There has been an acceptance that RCTs are the best way of establishing treatment effectiveness and a recognition that, while single studies are useful, pooling knowledge from a complete body of work is likely to provide the best evidence. Advances in methodology have been mirrored by the many advances in the field of reproductive medicine, such as assisted reproduction, assessment of male fertility, ovulation induction and laparoscopic surgery.

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